| 高效液相色谱法测定复方益母胶囊中阿魏酸的含量 |
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| 引用本文： | 张国民,齐赤虹,杨工昶,李志军.高效液相色谱法测定复方益母胶囊中阿魏酸的含量[J].中国中医药信息杂志,2008,15(2):48-50. |
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| 作者姓名： | 张国民 齐赤虹 杨工昶 李志军 |
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| 作者单位： | 1. 开封市食品药品检验所,河南开封,475002
2. 河南大学药学院,河南开封,475004 |
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| 摘 要： | 目的建立高效液相色谱法测定复方益母胶囊中阿魏酸含量的方法。方法采用ZORBAXSB-C18色谱柱，流动相为乙腈-0．2％磷酸水溶液（12：88），检测波长为316nm，流速为1．0mL／min。结果阿魏酸在0．8～13μg／mL范围内呈良好的线性关系（r=0．99999，17=6），平均回收率为103．0％（RSD=0．4％，17=5）。结论本法简单可行，准确度高，重现性好，回收率高，能有效控制复方益母胶囊的质量。
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| 关 键 词： | 复方益母胶囊 阿魏酸 高效液相色谱法 |
| 文章编号： | 1005-5304（2008）02-0048-03 |
| 收稿时间： | 2007-03-07 |
| 修稿时间： | 2007年3月7日 |
Content Determination of Ferulic Acid in Compound Prescribe Motherwort Herb Capusle by HPLC |
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| ZHANG Guo-min, QI Chi-hong, YANG Gong-chang, et al.Content Determination of Ferulic Acid in Compound Prescribe Motherwort Herb Capusle by HPLC[J].Chinese Journal of Information on Traditional Chinese Medicine,2008,15(2):48-50. |
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| Authors: | ZHANG Guo-min QI Chi-hong YANG Gong-chang |
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| Institution: | ZHANG Guo-min, QI Chi-hong, YANG Gong-chang, et al (1,Kaifeng Institute for Food and Drug Control Kaifeng 475002, China; 2.Medical College of Henan Province, Kaifeng 475001, China) |
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| Abstract: | Objective To estblish a HPLC method for content determination of ferulic acid in compound prescribe Motherwort Herb capusle. Method The column ZORBAXSB-C18 was used with Acetonitrile-0.2% phosphoric acid aqueous solution （12 ： 88） as mobile phase, and detective wavelength was 274 nm, the flow rate was 1.0 mL/min. Result Within the range of 0.8-13 μg, ferulic acid presented a fine linear relationship （r=0.999 99, n=6）. The average recovery was 103.0% （RSD=0.4%, n =5）. Conclusion The method is suitable, accuracy is high and reproducibility is good, recovery is high, and can control the quality of compound prescribe Motherwort Herb capusle. |
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| Keywords: | compound prescribe Motherwort Herb capsule： ferulic acid HPLC |
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