| PLGA的结构和分子量对纳曲酮微球体外释药的影响 |
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| 引用本文： | 王浩,栾瀚森,梅蕾,杨莉,侯惠民.PLGA的结构和分子量对纳曲酮微球体外释药的影响[J].中国医药工业杂志,2005,36(7):405-407. |
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| 作者姓名： | 王浩 栾瀚森 梅蕾 杨莉 侯惠民 |
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| 作者单位： | 药物制剂国家工程研究中心,上海,200437 |
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| 摘 要： | 制备了分子量、比旋度、摩尔比及分子链末端修饰不同的丙交酯-乙交酯共聚物,并测定理化参数.以其为载体制备纳曲酮微球,比较了体外释药速率.结果表明,用分子量较小、有光学活性、单体摩尔比较小、分子链末端未酯化的共聚物制备的微球体外释药速率较快.
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| 关 键 词： | 丙交酯-乙交酯共聚物 分子量 纳曲酮 微球 体外释药 |
| 文章编号： | 1001-8255(2005)07-0405-03 |
Effects of Structure and Molecular Weight of Poly (lactide-co-glycolide)on in vitro Release of Naltrexone Microspheres |
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| Authors: | WANG Hao LUAN Han-Sen MEI Lei YANG Li HOU Hui-min |
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| Abstract: | Poly(lactide-co-glycolide)(PLGA)with different molecular weights, monomer molar ratios, with or with-out optical activity and modification of chain terminal were prepared and the physicochemical properties were determined. Invitro release of naltrexone microspheres prepared with the various PLGA were compared. The results showed that the releasevelocity of microsphers prepared by PLGA with the lower molecular weight, optically active, lower lactide-glycolide molarratio and acetylated modification was faster. |
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| Keywords: | poly(lactide-co-glycolide) molecular weight naltrexone microsphere in vitro release |
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