Chronically inhaled salmeterol improves pulmonary function in heart failure |
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Authors: | Ng Tien M H Munger Mark A Lombardi William L Doing Tony H Ryujin Darin T Young David C Lugo Ralph A |
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Institution: | Department of Pharmacy Practice, University of Utah Health Sciences Center, Salt Lake City, UT, USA. tng@unmc.edu |
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Abstract: | Inhaled beta-agonists are commonly prescribed for the symptoms of exercise intolerance in heart failure despite a paucity of data regarding their safety and efficacy. This was a prospective, randomized, double-blind, double-dummy, placebo-controlled 14-day cross-over study to determine if chronic inhaled salmeterol therapy 84 microg every 12 hours improved pulmonary function without augmentation of neurohormonal systems or ventricular ectopy in 8 symptomatic heart failure subjects with left ventricular ejection fraction (LVEF) <40% and FEV1
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