卒中后抑郁的前瞻性随访调查

目的 研究卒中后抑郁(PSD)2周及3个月的患病率与相关因素.方法 对257例急性卒中患者进行2周及3个月前瞻性随访,调查卒中2周及3个月PSD患病率及相关因素.结果 卒中2周PSD患病率为32.59％,其中轻型抑郁20.92％,重型抑郁11.67％.卒中3个月PSD患病率为42.68％,其中轻型抑郁19.87％,重型抑郁22.81％.卒中2周PSD相关因素是人格特质中的内向特质(P=0.000)、是否合并有糖尿病(P=0.000)及神经功能缺损评分(P=0.000).卒中3个月PSD相关因素是急性期已经诊断PSD(P =0.000)及前循环卒中(P=0.04).结论 PSD患病率较高.卒中2周PSD发生与内向人格特质、合并糖尿病及神经缺损有关,3个月发生与急性期PSD及前循环卒中有关.

Prospective follow-up investigation for patients with post stroke depression

Objective To study the prevalence of depression at 2 weeks and 3 months after stroke and relevant factors of post stoke depression.Methods Two hundreds and fifty-seven patients with acute stroke were prospectively followed at 2 weeks and 3 months after stroke.Results Depressive rate 2 weeks after stroke was 32.59%, with a minor depression rate of 20.92%, and a major depression rate of 11.67%. Post stroke depression rate was 42.68% 3 months after stroke, including minor depression of 19.87% and major depression of 22.81%. Independent relevant factors for post stroke depression 2 weeks after stroke included introversion personality (P=0.000), diabetes (P=0.000), and severe neurologic impairment (P=0.000). Independent relevant factors for post stroke depression 3 months after stroke included depression diagnosed at the acute stage (P=0.000) and anterior circulation stroke (P=0.04).Conclusions Depression rate after stroke is high. Depression at 2 weeks after stroke is associated with introversion personality, severe neurologic impairment and diabetes. The independent relevant factors for depression at 3 months after stroke are depression diagnosed at the acute stage and anterior circulation stroke.