Autoantibodies against the common antigenic determinant of group a streptococcal polysaccharide and epithelial cells of mammalian thymus and skin |
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| Authors: | I. M. Lyampert L. V. Beletskaya N. A. Borodiyuk É. V. Gnezditskaya I. I. Rassokhina |
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| Affiliation: | (1) Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan;(2) Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan;(3) Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan;(4) Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan; |
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| Abstract: | A cross-reacting (CR) antigen, group A streptococcal polysaccharide and antigen of mammalian thymus and skin, was studied. The CR antigen was found in all adult human and embryonic tissues regardless of blood group, in all animals of different species studied, and in the tissues of rabbits immunized with streptococci and producing antibodies against A-polysaccharide. The results indicate that antibodies developing against the CR-determinant of A-polysaccharide and epithelial tissues belong to the class of autoantibodies. The reaction of these autoantibodies with the CR antigen is probably one cause of the development of autoimmune thymitis in rheumatic fever.Laboratory of Streptococcal Infections, N. F. Gamaleya Institute of Epidemiology and Microbiology, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR O. V. Baroyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 5, pp. 570–572, May, 1976. |
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| Keywords: | autoantibodies cross-reacting antigens streptococcus |
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