Carbazole alkaloids as new cell cycle inhibitor and apoptosis inducers from Clausena dunniana Levl |
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Authors: | Cui Cheng-Bin Yan Shao-Yu Cai Bing Yao Xin-Sheng |
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Affiliation: | a Beijing Institute of Biomedicine, Beijing 100091, People's Republic of China.b Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. |
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Abstract: | Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1 - 5 showed growth inhibitory activity (1, IC50 25 μg/ml) on human fibrosarcoma HT-1080 cells and cell cycle M-phase inhibitory (2, MIC 0.78 μg/ml) and apoptosis inducing (2, MIC 1.56 μg/ml; 3, MIC 25 μg/ml; 4, MIC 20 μg/ml; 5, MIC 30 μg/ml) activities on mouse tsFT210 cells, respectively, and 2 - 5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers. |
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Keywords: | Rutaceae Clausena Dunniana Carbazole Alkaloid 3-Methylcarbazole Murrayafoline A Girinimbine Mahanimbine Bicyclomahanimbine Cell Cycle Inhibitor Apoptosis Inducer |
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