| 通脉益智胶囊对VAD大鼠海马CA1区形态结构损害的干预作用 |
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| 引用本文： | 戴晓明,蒋凤荣,卞慧敏,陈亮,过伟峰.通脉益智胶囊对VAD大鼠海马CA1区形态结构损害的干预作用[J].东南大学学报(医学版),2009,28(2). |
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| 作者姓名： | 戴晓明 蒋凤荣 卞慧敏 陈亮 过伟峰 |
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| 作者单位： | 南京中医药大学,江苏,南京,210046 |
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| 基金项目： | 江苏省科技厅基础研究项目 |
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| 摘 要： | 目的:通过观察通脉益智胶囊对血管性痴呆(VAD)大鼠学习记忆能力和海马形态学变化的影响,探讨其防治VAD的作用.方法:应用高脂血症大鼠,采用脑缺血再灌注的方法建立VAD动物模型,利用Y型电迷宫检验大鼠的学习记忆能力,使用透射电镜和光镜观察分析海马CA1区形态结构的变化.结果:电迷宫实验表明模型大鼠学习记忆能力明显下降,而给予通脉益智胶囊组学习记忆能力改善,与模型组相比有显著性差异.形态学观察显示模型组大鼠海马CA1区神经细胞排列紊乱、数目减少,部分神经细胞核深染、固缩.电镜下神经细胞核膜皱褶内陷,核固缩,染色质凝集、边集,细胞器排列紊乱.通脉益智胶囊组的神经细胞形态与模型组相比在光镜、电镜下均有明显改善.结论:通脉益智胶囊对VAD大鼠海马CA1区的神经细胞具有保护作用,从而提高了学习记忆能力.
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| 关 键 词： | 血管性痴呆 通脉益智胶囊 海马 形态学 大鼠 |
Effect of Tongmaiyizhi capsule on the damage of hippocampal CA1 sector of VAD rats |
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| DAI Xiao-ming,JIANG Feng-rong,BIAN Hui-min,CHEN Liang,GUO Wei-feng.Effect of Tongmaiyizhi capsule on the damage of hippocampal CA1 sector of VAD rats[J].Journal of Southeast Univ: Medical Sci Ed,2009,28(2). |
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| Authors: | DAI Xiao-ming JIANG Feng-rong BIAN Hui-min CHEN Liang GUO Wei-feng |
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| Institution: | Nanjing Traditional Medicine University;Nanjing 210046;China |
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| Abstract: | Objective To explore the influence of Tongmaiyizhi capsule on ability of learning and memory and morphology of hippocampus in vascular dementia model rats.Methods Animal models with vascular dementia were prepared by cerebral ischemia-reperfusion at hyperlipidemia model rats.We observed the rats' ability of learning and memory in the y-type electric maze and the change of morphology of hippocampal CA1 sector by the TEM and light microscopy.Results The electric maze experiment showed that ability of learning... |
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| Keywords: | vascular dementia Tongmaiyizhi capsule hippocampus morphology rats |
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