| 海南青牛胆生物碱的研究 |
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| 引用本文： | 郭幼莹,林连波,符小文,小岛启介,荻原幸夫. 海南青牛胆生物碱的研究[J]. 海南医学院学报, 2004, 10(5): 293-297 |
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| 作者姓名： | 郭幼莹 林连波 符小文 小岛启介 荻原幸夫 |
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| 作者单位： | 1. 海南医学院化学教研室,海口,570102
2. 名古屋市立大学药学部,日本 |
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| 摘 要： | 目的:研究海南青牛胆(TinosporahainanesisH.S.LoetZ.X.Li)藤茎中的生物碱成分。方法:用溶剂提取及硅胶柱色谱分离纯化化学成分,通过MS,NMR,HMQC,HMBC及X-ray测定结构。结果:3种季铵生物碱以碘化物形式被分离并鉴定为:非洲防己碱(columbamine,I)、S-反式-N-甲基四氢非洲防己碱(S-trans-N-methyltetrahydrocolumbamine,II)及S-反式-轮环藤酚碱(S-trans-cyclanoline,III)。结论:III是新生物碱。
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| 关 键 词： | 海南青牛胆 S-反式-N-甲基四氢非洲防己碱 S-反式-轮环藤酚碱 |
| 文章编号： | 1007-1237(2004)05-0293-05 |
| 修稿时间： | 2004-08-10 |
STUDIES ON ALKALOIDS FROM TINOSPORA HAINANESIS |
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| GUO You-ying,LIN Lian-bo,FU Xiao-wen,et al.. STUDIES ON ALKALOIDS FROM TINOSPORA HAINANESIS[J]. Journal of Hainan Medical College, 2004, 10(5): 293-297 |
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| Authors: | GUO You-ying LIN Lian-bo FU Xiao-wen et al. |
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| Abstract: | Objective:To study the alkaloidal constituents of the vine stalk of Tinospora hainanesis. Methods:Using solvent extraction and silica gel column chromatography to separate and purify the chemicalconstituents. MS, NMR, HMQC, HMBC and X-ray were used to determine the structure of the isolatedconstituents. Results:Three quaternary alkaloids in the form of iodide were isolated and identified as:columbanine (I),S-trans-N-methyltetrahydrocolumbamine(II) and S-trans-cyclanoline ( III ). Conclusion:III is a new alkaloid. |
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| Keywords: | Tinospora hainanesis S-trans-N-methyltetrahydrocolumbamine S-trans-cyclanoline |
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