NDRG1在胃癌组织中的表达及其与侵袭转移的关系

目的 探讨NDRG1蛋白在胃癌组织中表达情况以及与临床病理指标和预后的关系.方法 应用免疫组化法检测110例胃癌及相应癌旁组织中NDRG1蛋白的表达,并分析其与胃癌患者临床病理指标及预后的相关性.结果 本组胃癌组织中NDRG1蛋白表达阳性率为71.8%,癌旁组织中阳性率为100%,并且胃癌组织中NDRG1蛋白多为低表达,而癌旁组织多为高表达.NDRG1蛋白表达与胃癌浸润深度、TNM分期以及有无淋巴转移具有相关性,而与患者年龄、性别、分化程度、大体类型、远处转移无关.NDRG1蛋白低表达胃癌患者预后较差,1、3、5年总生存率和无病生存率分别为84.2%、53.9%、21.1%和60.5%、31.6%、19.7%.结论 NDRG1在胃癌组织中多呈低表达,与肿瘤的浸润、转移密切相关,可能是胃癌发病及肿瘤转移的一个候选抑癌基因,对胃癌发病及转移的早期诊断和预后判断有重要指导意义.

The NDRG1 expression and the prognosis in patients of gastric carcinoma

Objective To explore the expression of N-myc downstream regulated gene 1 (NDRG1) in gastric carcinoma and the relationship with clinicopathological parameters and prognosis. Methods The expression of NDRGI was detected by immunohisto chemistry in formalin-fixed and paraffin-embedded sections with a total of 220 specimens including 110 gastric carcinoma and 110 corresponding paraneoplastic tissue. The correlation between clinicopathological parameters and the expression of NDRG1 in gastric carcinoma were also analyzed. Results Low expression of NDRG1 was detected in most gastric carcinoma sections. Among the gastric cancer tissues, NDRG1 protein expression was significantly lower in tumors with more advanced pathological stage, local tumor invasion and lymphatic metastases. There was no significant difference in sex, age, tumor differentiation and gross types of the tumor. The 1-, 3- and 5 year survival and disease free survival in patients with low NDRG1 protein expression was 84.2%, 53.9%, 21.1%, and 60.5%, 31.6%, 19.7%, respectively, which was signifivantly poorer when compared with patients with high NDRG1 protein expression. Conclusion The expression of NDRG1 is low in the majority of patients with gastric carcinoma, which was in a close relationship with advanced stage, local invasion and lymphatic metastases of gastric carcinoma. NDRG1 may be a candidate metastasis suppressor gene.