非胰岛素依赖型糖尿病患者运动前后血脂和白蛋白变化对胰岛素受体的影响

为广解急性运动前后血脂和白蛋白水平对胰岛素受体结合的影响．对３８例非肥胖非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者和３７名正常人进行了３０分钟中等强度运动前后红细胞膜胰岛素受体的测定，并对受体参数与血脂、白蛋白之间进行了相关分析。结果显示急性运动前ＮＩＤＤＭ组高亲和力亲和常数（Ｋ＿１）与总胆固醇和白蛋白水平呈显著负相关（ｒ＝－０．４７３，Ｐ＝０．０１；ｒ＝－０．４８３，Ｐ＝０．０１）。低亲和力亲和常数（Ｋ＿２）与甘油三酯呈显著正相关（ｒ＝０．５０３，Ｐ＝０．０１）．与高密度脂蛋白胆固醇呈显著负相关（ｒ＝－０．４８０；Ｐ＝０．０１），急性运动后血脂和白蛋白浓度的变化与受体参数之间未发现有意义的相关关系。提示ＮＩＤＤＭ病人基础血脂和白蛋白水平是影响胰岛素受体亲和力的重要因素。

Correlative study of erythrocyte membrane insulin re-ceptor with blood lipids and albumin in non obeseNIDDM patients before and after exercise

o understand the effects of the levels of bloodlipids and albumin on insulin receptor binding beforeand after acute exercise, we measured insulin bindingto erythrocyt membrane before and after 30 minutesrnoderate exercise in thirty-eight non-obese noninsulin-dependent diabetics (NIDDM) and thirty-seven normalsubjects. The correlations between parameters of in-sulin receptor and blood lipids and albumin were alsostudied. The results showed that before acute exercise ,the level of high-binding-affinity (K 1) was significantlycorrelated with that of total cholesterol (r= 0. 473 ,P = 0. 013 ) , and albumin (r = - 0. 483 , P = 0. o11 ) .The low-binding-affinity (K2) was significantly corre-lated with that of triglycerides (r= 0. 503 , P= 0. 008)and high-density-lipoprotein (HDL) cholesterol (r=-0. 480, P= 0. 011). After acute exercise, no significant correlations between the parameters of insulin re-ceptor, blood lipids and albumin were found. Thesesuggest that blood lipids and albumin are important in-fluential factors for affinities of insulin receptor.