胃食管反流食管外症状的治疗研究

目的探讨胃食管反流食管外症状的诊断及治疗。方法 218例伴食管外症状的GERD患者随机分为3组,给予莫沙必利+奥美拉唑20mg每日1次(A组)、奥美拉唑20mg每日1次(B组)及莫沙必利+奥美拉唑20mg每日1次(C组)治疗。观察治疗6个月的症状及体征情况。结果 B组与A、C两组症状有效率及痊愈率差异显著(P<0.05);然而,A组与C组无显著差异(P>0.05),但C组显示比A组高18%的痊愈率。此外,B组与A、C两组体征有效率无显著差异(P>0.05)。但C组与A、B两组痊愈率差异显著(P<0.05)。结论双倍剂量质子泵抑制剂+莫沙必利可有效控制胃食管反流食管外症状。

Treatment of Extraesophageal Sympotoms in Patients with Gastroesophageal Reflux

Objective To discuss the diagnosis and treatment of extraesophageal sympotoms in patients with gastroesophageal reflux.Methods A total of 218 patients with extraesophageal sympotoms were distributed into three groups:mosapride plus omeprazole 20mg/d(A group),omeprazole 20mg/d(B group) and mosapride plus omeprazole 20mg/d(C group).The signs and sympotoms were estimated after fowlling-up 6 months.Results The difference was statistically significant(P<0.05)between A groups and B groups with regard to effective rate or cure rate for sympotom.The defference was statistically significant(P<0.05)between C groups and B groups with regard to effective rate or cure rate for sympotom.However,the defference was not statistically significant(P>0.05) between A groups and C groups,but the cure rate of C groups was 18%high than that in the A groups.In addition,the difference was not statistically significant(P>0.05) between B groups and A groups with regard to effective rate for sign.The difference was not statistically significant(P>0.05) between B groups and C groups with regard to effective rate for sign.However,the difference was statistically significant between B groups and C groups with regard to cure rate(P<0.05).Conclusion We suggest that mosapride plus double dose proton pump inhibitor may prove to be an effective method for treating extraesophageal sympotoms in patients with gastroesophageal reflux.