| Wnt信号通路异常激活在卵巢上皮性癌中的作用 |
| |
| 引用本文： | 戴颖青 妇产科,南京,,王安明 妇产科,南京,.Wnt信号通路异常激活在卵巢上皮性癌中的作用[J].医学研究生学报,2012,25(3):312-315. |
| |
| 作者姓名： | 戴颖青 妇产科 南京 王安明 妇产科 南京 |
| |
| 作者单位： | 戴颖青 (南京大学医学院临床学院(南京军区南京总医院)妇产科,南京,210002) ； 王安明 (南京大学医学院临床学院(南京军区南京总医院)妇产科,南京,210002) ； |
| |
| 摘 要： | Wnt信号通路是重要的细胞信号传导通路,参与了从胚胎到成体的一系列调控,在细胞增殖、分化、运动、黏附及机体发育中起重要的调节作用,异常激活会导致相关疾病尤其是肿瘤的发生。人类卵巢上皮性癌的发生发展过程中存在经典Wnt信号通路的异常激活。研究发现,在卵巢上皮性癌细胞中Wnt信号通路相关蛋白β-连环蛋白(β-catenin)、Wnt-1、c-Myc、细胞周期蛋白D1(cyclinD1)的表达明显增高,其中β-catenin蛋白与癌细胞的异常增殖及转移有密切关系。针对Wnt信号通路变化的研究对卵巢上皮性癌的临床诊断与治疗有重要意义。
|
| 关 键 词： | 卵巢上皮性癌 Wnt β-连环蛋白 Wnt-1蛋白 c-Myc蛋白 细胞周期蛋白D1 |
Abnormal activation of Wnt signaling pathway in epithelial ovarian cancer |
| |
| DAI Ying-qing,WANG An-ming reviewing,LIU Qi.Abnormal activation of Wnt signaling pathway in epithelial ovarian cancer[J].Bulletin of Medical Postgraduate,2012,25(3):312-315. |
| |
| Authors: | DAI Ying-qing WANG An-ming reviewing LIU Qi |
| |
| Institution: | checking(Department of Obstetrics and Gynaecology,School of Medicine,Nanjing Univercity/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China) |
| |
| Abstract: | The Wnt signaling pathway is an important cell signaling pathway in cell metabolism,involved in the regulation of embryo growing,cell proliferation,cell differentiation,cell adhesion,and body development.Abnormal activation of the pathway may induce carcinogenesis,including epithelial ovarian cancer.Overexpressed β-catenin,Wnt-1,c-Myc and cyclinD1,as the proteins of the pathway,play a very important role in epithelial ovarian cancer,and β-catenin is closely associated with the abnormal growth and metastasis of cancer cells.An insight into the changes of the Wnt signaling pathway is of great significance to the clinical diagnosis and treatment of epithelial ovarian cancer. |
| |
| Keywords: | Epithelial ovarian cancer Wnt signaling pathway β-catenin Wnt-1 protein c-Myc protein cyclinD1 |
| 本文献已被 CNKI 等数据库收录！ |
|
