| 银杏叶及其化学成分对CYP3A4和CYP2C9影响的研究进展 |
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| 引用本文： | 潘沛. 银杏叶及其化学成分对CYP3A4和CYP2C9影响的研究进展[J]. 医学综述, 2012, 18(5): 750-753 |
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| 作者姓名： | 潘沛 |
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| 作者单位： | 上海交通大学医学院附属第三人民医院药剂科,上海,201900 |
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| 基金项目： | 上海市卫生局科研项目,上海医院药学科研基金,上海交通大学医学院医院药学科研基金 |
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| 摘 要： | 银杏叶是临床上使用广泛的中草药之一,主要化学成分包括黄酮类和萜类内酯两大类。近年来,国内外大量的研究表明银杏叶及其化学成分能够影响细胞色素P450酶的表达,并通过细胞色素P450酶影响其他药物的代谢。现从银杏叶及其化学成分对CYP3A4和CYP2C9的影响,及其通过CYP3A4、CYP2C9影响其他药物代谢等方面进行综述。
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| 关 键 词： | 银杏叶 银杏叶提取物 CYP3A4 CYP2C9 |
Effects of Ginkgo Biloba and Its Extracts on CYP3A4 and CYP2C9 |
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| PAN Pei. Effects of Ginkgo Biloba and Its Extracts on CYP3A4 and CYP2C9[J]. Medical Recapitulate, 2012, 18(5): 750-753 |
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| Authors: | PAN Pei |
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| Affiliation: | .(Departement of Pharmacy,No.3 People′s Hospital Affiliated to Shanghai Jiaotong University of Medicine,Shanghai 201900,China) |
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| Abstract: | Gingko biloba(GB)has been used in traditional Chinese medicine for thousands of years which contains ginkgo flavonol glycosides and terpenoids.Currently,a lot of researches showed that GB and its extracts(GBE)could influence the expression of CYP450,or effect on the other drugs by CYP3A4 and CYP2C9.Here is to make a review on the influences on the expression of CYP3A4 and CYP2C9 by GB and GBE,and whose effects on the metabolism of the other drugs by CYP3A4 and CYP2C9. |
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| Keywords: | Ginkgo biloba Ginkgo biloba extract CYP3A4 CYP2C9 |
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