| 雌激素对骨质疏松大鼠牙槽骨改建及IL-1表达的影响 |
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| 引用本文： | 李潇,丁寅,金作霖,金钫. 雌激素对骨质疏松大鼠牙槽骨改建及IL-1表达的影响[J]. 牙体牙髓牙周病学杂志, 2000, 10(1): 16-18 |
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| 作者姓名： | 李潇 丁寅 金作霖 金钫 |
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| 作者单位： | 第四军医大学口腔医学院,陕西,西安,710032 |
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| 摘 要： | 目的：探讨雌激素对骨质松牙槽骨改建中ＩＬ－１的表达与分布的影响及意义。方法：在建立ＳＤ大鼠骨质疏松模型的基础上，用免疫组化染色方法，观察ＩＬ－１在骨质疏松以及雌激素治疗后的牙槽骨中的表达变化。结果：ＩＬ－１在骨质疏松牙槽骨中有较强的表达，阳性反应主要分布于破骨细胞，部分成骨细胞及骨细胞中，而在用雌激素治疗骨质疏松组中，ＩＬ－１的阳性表达程度明显下降。
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| 关 键 词： | 雌激素 骨质疏松 牙槽骨 IL－1 |
| 修稿时间： | 1998-12-24 |
Effects of estrogen on the alveolar bone remodeling and the expression of IL-1 osteoporotic rats |
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| LI Xiao,DING Yin,JIN Zuo-lin,et al School of Stomatology,The Fourth Military Medical University,Xi'an $$$$. Effects of estrogen on the alveolar bone remodeling and the expression of IL-1 osteoporotic rats[J]. Chinese Journal of Conservative Dentistry, 2000, 10(1): 16-18 |
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| Authors: | LI Xiao DING Yin JIN Zuo-lin et al School of Stomatology The Fourth Military Medical University Xi'an $$$$ |
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| Affiliation: | LI Xiao,DING Yin,JIN Zuo-lin,et al School of Stomatology,The Fourth Military Medical University,Xi'an 710032$$$$ |
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| Abstract: | AIM:To investigate the effects of estrogen on the expression and distribution of IL-1 in the remodeling of osteoporotic alveolar bone. METHODS:By immunohistochemical staining technique,we studied the expression and distribution of IL-1 in alveolar bone of osteoporosis and estrogen-stimulated ovariectomized(OVX) rats. RESULTS:The positive IL-1 immunoreactivities were mainly located in the osteoclasts, some of the osteoblasts and osteocytes.The positive reaction was obviously decreased in the estrogen-stimulated OVX rats. CONCLUSION: Estrogen could influence the remodeling of osteoporotic alveolar bone by means of inhibiting the expression of IL-1. |
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| Keywords: | estrogeni osteoporosis alveolar bone IL-1 |
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