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Cytotoxic,mutagenic, and cell-cell communication inhibitory properties of DDT,lindane, and chlordane on Chinese hamster cellsin vitro
Authors:G. Tsushimoto  C. C. Chang  J. E. Trosko  F. Matsumura
Affiliation:1. Pesticide Research Center, Michigan State University, 48824, East Lansing, Michigan
2. Department of Pediatrics and Human Development, Michigan State University, 48824, East Lansing, Michigan
Abstract:The cytotoxicity, mutagenicity, andin vitro inhibition of metabolic cooperation of DDT, lindane, and chlordane were studied with Chinese hamster V79 cells. The results showed differential cytotoxicity of these three pesticides (lindane < DDT < chlordane). There was no detectable mutagenic activity of any of these pesticides, using two genetic markers (6-thioguanine and diphtheria toxin resistance). DDT and lindane, however, were shown to have properties similar to 12-O-tetradecanoylphobol-13-acetate (a powerful mouse skin tumor promoter). Above what appeared to be a threshold level, there was a clear dose response of DDT and lindane in thein vitro cell-cell communication assay. Chlordane, which was the most cytotoxic pesticide tested, did not inhibit metabolic cooperation as significantly as did DDT or lindane. The role of these pesticides in carcinogenesis was speculated as being their tumor promoting properties, either at non-cytotoxic levels by mimicing TPA-like membrane alterations or at cytotoxic levels by mimicing partial hepatectomy.
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