| 用双剂量实验数据分析药物的米氏消除参数的识别问题 |
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| 引用本文： | 郭政 吴帆. 用双剂量实验数据分析药物的米氏消除参数的识别问题[J]. 生物医学工程学杂志, 1994, 11(2): 133-137 |
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| 作者姓名： | 郭政 吴帆 |
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| 作者单位： | 哈尔滨医科大学!哈尔滨150086(郭政，李霞)，黑龙江省邮电学校!哈尔滨150080(吴帆) |
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| 摘 要： | 本文分析了给药剂量对按一级过程吸收，米氏过程消除药物的血药浓度的峰值与达峰时间的影响。并据此讨论了利用较少的双剂量实验数据改善识别米氏参数的方法。
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| 关 键 词： | 米氏动力学 参数识别 药物动力学 |
On the Identification of Michaelis-Menten Elimination Parameters Based on Two Sets of Dose-Response Data |
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| Guo Zheng Li Xia. On the Identification of Michaelis-Menten Elimination Parameters Based on Two Sets of Dose-Response Data[J]. Journal of biomedical engineering, 1994, 11(2): 133-137 |
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| Authors: | Guo Zheng Li Xia |
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| Abstract: | In this paper is analysed the influence of the dose on the peak value and peaK time of the pias-ma concentration vs time curve of drugs which obey first - order absorption and Michaelis -Menten elimination kinetics. A method usable to identify the Michaelis - Menton elimination p(?) rameters based on two sets of dose - response data is suggested |
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| Keywords: | : Michaelis-Menten kinetics parameter identification pharmacokinetics |
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