原发性高血压患者外周血红细胞免疫功能的变化和血浆TXB_2水平的相关性分析

目的：探讨了原发性高血压患者外周血红细胞免疫功能的变化及其与血浆血栓素B2（TXB2）水平的相关性。方法：应用放免法和免疫法对48例原发性高血压患者进行了红细胞免疫功能和血浆TXB2检测,并与35名正常健康人作比较。结果：原发性高血压患者RBC-C3bRR水平明显降低（P〈0.01）,而血浆TXB2水平显著地升高（P〈0.01）,RBC-C3bRR水平与TXB2水平呈显著的负相关（r=-0.3812,P〈0.05）,RBC-ICRRR水平显著地高于正常人组（P〈0.01）,与血浆TXB2水平呈明显正相关（r=0.3682,P〈0.05）。结论：原发性高血压患者存在免疫调节的紊乱,免疫功能低下与血浆TXB2水平有一定的相关性。

Study on the Relationship Between Peripheral Blood Red Blood Cells Immunofunction Status and Plasma Thromboxane B2 (TXB2)Levels in Patients with Essential Hypertension

Objoctive To investigate the relationship between changes of peripberal blood red blood cells immunofunction status and plasma thromboxane B2 （TXBz） levels in patients with essential hypertension. Methods RBC immunofunction status was studied with immunologic methods and plasma TXB2 levels were measured with PdA in 48 patients with essential hypertension and 35 controls. Results Levels of RBC - C3bRR were significantly lower and levels of plasma TXB2 were significantly higher in the patients than those in controls （P〈0.01）, These two variables were significantly negatively correlated （r = -0. 3812, P 〈0.05）. The RBC - ICRtLR levels were significantly higher in the patients （P 〈 0.01 ） and were positively correlated with levels of TXB2 （ r = 0. 3682, P 〈 0.05）. Conclusion There were disturbances of RBC immuno-regulation with suppressed immunofunction and nigher TXB2 levels in patients with essential hypertension.