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Mild emphysema: a novel method using formalin-fixed lungs for computed tomography and pathological analyses |
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| Authors: | T. Hamada T. Sasaguri A. Tanimoto Y. Sasaguri M. Hisaoka H. Hashimoto K. Hirakata H. Nakata |
| Affiliation: | (1) Deparment of Surgical Pathology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, 807 Kitakyushu, Japan;(2) Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan;(3) Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan;(4) Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan |
| Abstract: | We evaluated a novel method of computed tomography (CT) analysis using formalin-fixed lungs of autopsy cases with mild emphysema. Eight formalin-inflated lungs (FILs) obtained at autopsy were examined using CT after draining off the formalin and air inflation with an air pump, and subjected to pathological study including pathological scoring of emphysema and microscopic image analysis (MIA). Satisfactory CT examination was carried out within 5 h of lung fixation. The mean alveolar area determined by MIA correlated highly with the lung volume (r=0.845) and CT score (r=0.722). This method is simple compared with conventional polyethylene glycol fixation for CT and enables CT examination of resected lungs without anxiety about biohazards. Mild emphysema can be detected by MIA. |
| Keywords: | Emphysema of FILs Post-mortem examination Computed tomography Microscopic image analysis |
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