国产左旋卡尼汀佐治不稳定型心绞痛临床观察

目的评价国产左旋卡尼汀对不稳定型心绞痛的临床疗效。方法选择不稳定型心绞痛患者112例,随机分为A、B两组,A组给予常规治疗;B组在常规治疗基础上加国产左旋卡尼汀3.0g静滴,每日1次,并观察下述指标:①静息心电图;②心绞痛发作的次数;③心绞痛发作持续的时间;④不良反应。治疗结束评定两组心绞痛稳定情况。结果B组可明显改善静息心电图心肌缺血的表现,总有效率为80.3%,与A组(60.7%)比较差异有显著意义(P<0.05);B组与A组心绞痛的总有效率分别为96.42%、91.07%,P>0.05,但左卡组心绞痛显效率较常规组高(87.50%/64.28%)。结论国产左旋卡尼汀佐治不稳定型心绞痛安全有效,值得临床推广。

Effects of indigenous L-carnitine in patients with unstable angina pectoris

ObjectiveTo observe the clinical effects of indigenous L-carnitine in the treatment of patients with unstable angina pectoris.Methods112 cases of patients with unstable angina pectoris randomly received routine treatment or L-carnitine(3.0 g/d)with routine treatment.ResultsThe effective rates of angina pectoris, ischemic ST-T changes on ECG of L-carnitine group were 96.42%,80.3% (vs the group of routine treatment 91.07%,60.7%),respectively.No adverse reactions related to the drug were observed.ConclusionThe indigenous L-carnitine with routine treatment might be a safe and effective way to treat the patients with unstable angina pectoris.