心病瘀血舌与TXB2、6-Keto-PGF1α的相关性研究

目的：从“TXA2-PGI2”平衡失调探讨心病瘀血舌形成的病理机制。方法：随机选择72例心病瘀血舌患者、30例心病非瘀血舌患者、30例非心病瘀血舌患者与20例健康人,采用RIA法检测血浆TXB2、6-Keto-PGF1α。结果：心病瘀血舌组的TXB2、TXB2/6-Keto-PGF1α显著高于对照组和心病非瘀血舌组（P〈0.01）,6-Keto-PGF1α显著低于对照组和心病非瘀血舌组（P〈0.01）。心病瘀血舌患者不同证型组的TXB2、TXB2/6-Keto-PGF1α均较对照组显著增高（P〈0.05,P〈0.01）,6-Keto-PGF1α均较对照组显著降低（P〈0.01）。结论：TXA2-PGI2失衡是心病瘀血舌形成的关键病理基础;综合观察TXB2、6-Keto-PGF1α、TXB2/6-Keto-PGF1α的异常程度可作为诊断心病瘀血舌的客观指标。

Correlativity between blood-stasis-tongue subjects with cardiopathy and TXB2,6-Keto-PGF1α

Objective ：to explore the pathologic mechanism of blood-stasis-tongue subjects with cardiopathy （BSTC） from the unbalance of the levels of thromboxane A2 （ TXA2 ） and prostaglandin I2 （ PGI2 ）. Methods：72 cases with BSTC, 30 cases with non-blood-stasis- tongue subjects with eardiopathy （NBSTC） and 30 cases with blood-stasis-tongue subjects with non-eardiopathy （BSTNC） were observed at random ,20 healthy cases as control. The levels of thromboxane B2 （TXB2 ） and 6-Keto-PGF1α in blood plasma were detected by RIA. Results：The levels of TXB2 and TXB2/6-Keto-PGF1α in the group of BSTC was significantly higher than those in the groups of control and NBSTC （P 〈 0. 01 ） , and the level of 6-Keto-PGF1α was significantly lower than that in the groups of control and NBSTC （P 〈0. 01 ）. The levels of TXBz and TXB2/6-Keto-PGF1α in different syndrome type groups in patients with BSTC was significantly higher than those in the control group （P 〈 0. 05,P 〈 0. 01 ） , and the level of 6-Keto-PGF1α was significantly lower than that in the control group （P 〈0. 01 ）. Conclusion： The unbalance of the levels of TXA2 and PGI2 was the critical pathologic basis in the formation of BSTC. It was thought that the synthetic observation of the abnormal degree of the levels of TXB2 /6-Keto-PGF1α and TXB2/6-Keto-PGF1α could be used as an objective index for the diagnosis of BSTC.