| 消炎痛对中晚期原发性肝癌病人NK细胞及T淋巴细胞亚群？… |
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| 引用本文： | 袁伟建,陈凤英.消炎痛对中晚期原发性肝癌病人NK细胞及T淋巴细胞亚群？…[J].湖南医科大学学报,2000,25(6):583-584. |
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| 作者姓名： | 袁伟建 陈凤英 |
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| 作者单位： | 湖南医科大学附属湘雅医院内科,长沙 |
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| 摘 要： | 观察中晚期原发性肝癌病人在口服呋喃氟尿嘧啶的基础上加用消炎痛（吲哚美辛）（治疗组）和不加用消炎痛（对照组）外周血自然杀伤（ＮＫ）细胞及Ｔ淋巴细胞亚群的变化。结果发现：治疗组治疗后ＮＫ细胞活性较治疗前及较对照组治疗后显著提高（Ｐ〈０．０５，Ｐ〈０．０１），而Ｔ淋巴细胞亚群的变化差异无显著性。提示消炎痛能增强中晚期原发性肝癌ＮＫ细胞的活性。
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| 关 键 词： | T淋巴细胞亚群 中晚期原发性肝癌 NK细胞 |
Effect of indomethacin on natural killer(NK) cell and T lymphocyte subsets from patients with hepatocellular carcinoma] |
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| W J Yuan,F Y Chen,G Y Zhang.Effect of indomethacin on natural killer(NK) cell and T lymphocyte subsets from patients with hepatocellular carcinoma][J].Bulletin of Hunan Medical University,2000,25(6):583-584. |
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| Authors: | W J Yuan F Y Chen G Y Zhang |
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| Institution: | Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008. |
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| Abstract: | Twenty-one patients with advanced hepatocellular carcinoma were randomly divided into two groups. They were orally given tegafur 200 mg three times a day with(Group I, n = 11) or without(Group II, n = 10) indomethacin 25 mg three times a day for 7 days. Before and after the therapies the NK cell and T-lymphocyte subset activity in peripheral blood were measured. The results showed that NK cell activity in Group I was significantly higher than that in Group II(P < 0.01) and that before the treatment as well(P < 0.05). T-lymphocyte subsets had no significant difference between the two groups and before or after the therapy. It is suggested that the indomethacin might improve the NK activity of the patients with advanced hepatocellular carcinoma. |
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