视神经脊髓炎患者血清及脑脊液中B淋巴细胞活化因子的表达水平与临床意义

目的 探讨视神经脊髓炎患者血清及脑脊液中B淋巴细胞活化因子的表达水平及其临床意义。方法 选取2011年1月-2015年1月本院收治的视神经脊髓炎(NMO)患者50例及多发性硬化(MS)患者50例,将其分别作为NMO组与MS组,另选取同期于本院进行体检的非炎性神经系统疾病患者50例作为对照组,对3组血清及脑脊液中的B淋巴细胞活化因子(BAFF)水平进行检测。结果 与对照组比较,NMO组与MS组血清中BAFF水平均无明显变化(P>0.05),而NMO组与MS组脑脊液中BAFF水平均明显升高(P<0.05); 与MS组比较,NMO组脑脊液中BAFF水平明显升高(P<0.05)。NMO组与MS组脑脊液中BAFF水平与EDSS评分呈正相关,即脑脊液中BAFF水平随EDSS评分升高而升高(r=0.887,0.885,P<0.01)。结论 视神经脊髓炎患者脑脊液中的B淋巴细胞活化因子水平较高,可能是诊断视神经脊髓炎的重要标志物,对疾病严重程度的判定具有重要的临床意义。

The expression level and clinical significance of B lymphocyte activation factor in serum and cerebrospinal fluid of patients with optic nerve myelitis

ObjectiveTo investigate the and its clinical significance of B lymphocyte activation factor in serum and cerebrospinal fluid of the optic myelitis patients.Methods 50 patients with optic nerve myelitis(NMO)and 50 patients with multiple sclerosis(MS)were selected in our hospital from January 2011 to January 2015,and were respectively as NMO group and MS group.Otherwise,50 patients with no inflammatory diseases of the nervous system in our hospital for physical examination during the same period were selected as control group.the expression level of B lymphocyte activating factor(BAFF)in serum and cerebrospinal fluid of three groups were tested.Results compared with control group,the expression level of serum BAFF were no obvious changes in NMO group and MS group(P > 0.05),and BAFF levels were significantly elevated in the cerebrospinal fluid of NMO group and MS group(P < 0.05).Compared with MS group,BAFF levels were significantly increased in cerebrospinal fluid of NMO group(P < 0.05).EDSS score in NMO and MS group was positively related to the BAFF expression level in cerebrospinal fluid,the BAFF expression level levels in the cerebrospinal fluid rised with EDSS score(r=0.887,0.885,P < 0.01).Conclusion B lymphocyte activation factor levels in the cerebrospinal fluid of patients with optic nerve myelitis were higher,it might be important markers for diagnosis of optic myelitis,it had important clinical significance to determine the severity of disease.