整合调控技能训练对精神分裂症患者生活质量的影响

目的:探讨整合调控技能训练对精神分裂症患者生活质量的影响。方法:本研究采用随机、空白对照开放性前瞻性研究。选取符合国际疾病分类第十版(ICD-10)中精神分裂症确诊标准的住院患者共85例,随机分为研究组(整合调控技能训练+常规抗精神病药物治疗,n=41)和对照组(常规抗精神病药物治疗,n=44),应用简明精神病量表(BPRS)和世界卫生组织生存质量测定量表简表(WHOQOL-BREF)在基线及4周末进行评估。结果:经4周干预后,研究组在BPRS总分及各项因子得分上均低于对照组,差异有统计学意义(t=9.98,2.33,2.98,2.03,2.20;P0.05)。除社会关系领域外,研究组在WHOQOL-BREF总分、生理领域、心理领域和环境得分均显著高于对照组(t=4.49,2.04,2.07,2.27;P0.05)。结论:整合调控技能训练能够有效地改善精神分裂症患者的生活质量,为其早日回归社会提供新的途径。

Effects of Integrated Regulation Training on Quality of Life for Patients with Schizophrenia

Objective :To explore the efficacy of Integrated Regulation Training (IRT )on quality of life for patients with schizophrenia .Methods :In this randomized controlled ,open label ,prospective study ,85 patients with schizophre‐nia who met the edition international classification of diseases (ICD - 10)criteria for schizophrenia ,which were ran‐domly assigned to treatment group(IRT combined with general antipsychotic drugs and nursing ,n = 41) ,and control group(general antipsychotic drugs and nursing ,n = 44) .Brief Psychiatric Rating Scale(BPRS)and World Health Or‐ganization Quality of Life - Brief(WHOQOL - BREF)were used to assess the efficacy at baseline and 4 blindly .Re‐sults :After 4 week treatment ,regarding BPRS total score and any other terms suggested that the treatment group were lower than the control group(t = 9 .98 ,2 .33 ,2 .98 ,2 .03 ,2 .20 ;P < 0 .05) .Furthermore ,the treatment group’s to‐tal score of WHOQOL - BREF ,psychological factor ,environment factor and physiological factor was higher than the control group(t = 4 .49 ,2 .04 ,2 .07 ,2 .27 ;P < 0 .05) ,but not in the social relation factor .Conclusion :Effects of IRT can effectively improve the quality of life in patients with schizophrenia ,which will pose a new way to early rehabilitation of patients with schizophrenia .