舒肝解郁胶囊与西酞普兰治疗产后抑郁症的临床疗效比较

目的:比较舒肝解郁胶囊与西酞普兰治疗产后抑郁症患者的治疗效果和安全性。方法:采用随机数字表法将80例产后抑郁症患者随机分为舒肝解郁胶囊治疗组(观察组)和西酞普兰治疗组(对照组)。观察组给予舒肝解郁胶囊口服治疗,对照组给予西酞普兰口服治疗。对两组在治疗前和治疗后1,2,4,6周评定17项汉密尔顿抑郁量表(HAMD),临床总体印象量表-病情严重程度量表(CGI-SI),不良反应症状量表(TESS)及临床疗效评估。结果:1观察组与对照组痊愈率、显效率、有效率、无效率、总有效率差异不显著;2与治疗前相比,观察组和对照组的HAMD和CGI-SI得分均显著下降(P0.05),两组HAMD、CGI-SI减分差异不显著;3观察组不良反应(6例)显著少于对照组(11例)(P0.05)。结论:舒肝解郁胶囊与西酞普兰治疗产后抑郁症疗效相当,且副作用小,安全性好。提示,基于产后抑郁症的生理特点和社会角色,中药合成剂治疗产后抑郁症是更佳的选择。

Comparative Observation of Clinical Effect on Postpartum Depression Treated with Suganjieyu Capsules and Citalopram Tablets

Objective :To explore the difference on clinical effect on postpartum depressions treated with Suganjieyu Capsules and Citalopram Tablets .Methods :80 postpartum depression patients were enrolled as research group .The research group was divided into Suganjieyu Capsules treated group (observation group ,n = 40)and Citalopram Tab‐lets treated group(control group ,n = 40)by the method of the random number table .The research groups were per‐formed clinical randomized double blind control test and were assessed with 17 - item Hamilton Depression Scale (HAMD)and Clinical Global Impression - severity of illness scale (CGI - SI) ,and Treatment Emergent Symptom Scale(TESS) .Results :① There were no differences on the curative rate ,the significant efficiency ,the effective rate , inefficiency rate ,and the total effective rate between experimental group and the control group .② Compared with pri‐or - treatment ,the HAMD and CGI - SI scores of postpartum depressions were decreased significantly post - treat‐ment(P < 0 .05) .No differences were found on the reductive score value of HAMD and CGI - SI between experimen‐tal group and the control group .③ Adverse reactions in the observation group were significantly less than the control group(P < 0 .05) .Conclusion :Clinical efficiency on postpartum depressions treated with Suganjieyu Capsules is quite than Citalopram Tablets ,has little side effects ,and good security .It further suggests that it is better to treat postpar‐tum depressions by using the Traditional Chinese Medicine Compound base on their physiological characteristics and social roles .