重型脑损伤患者高压氧治疗前后血清SOD,LPO含量变化

目的探讨高压氧(HBO)对重型脑损伤患者疗效及对血清脂质过氧化物(LPO)、超氧化物歧化酶(SOD)的影响。方法55例重型脑损伤患者于病情稳定后3 d行高压氧(HBO)治疗,分别于首次治疗前1 h、治疗后48 h、第20天行血清SOD,LPO测定,并与未行HBO治疗的54例患者对照。结果重型脑损伤患者治疗前两组患者SOD,LPO含量无显著差异(P>0.05);经治疗48 h后,两组患者SOD水平均上升,LPO水平均下降,两组比较无显著差异(P>0.05);治疗后第2周,HBO组血清SOD水平较常规对照组明显升高,LPO明显降低,两组比较差异显著(P<0.01)。HBO组恢复良好率明显高于对照组,死亡率明显低于对照组(P<0.05)。结论高压氧可有效抑制氧自由基生成,减轻脂质过氧化反应,对脑组织的结构与功能起保护作用,明显改善重型脑损伤患者的预后。

Changes in SOD and LPO of Severe Cerebral Damage Patients after Hyperbaric Oxygen Therapy

Objective To discuss the effect of hyperbaric oxygen(HBO) on severe cerebral damage patients and on their lactoperoxidase(LPO) and superoxide dismutase(SOD) levels.Methods HBO therapy was applied to 55 patients with severe cerebral damage three days after their conditions got stable.Their SOD and LPO levels were measured respectively an hour before initial therapy,48 hours and the second week after the beginning of HBO therapy,and they were compared with that of 54 control patients to whom HBO was not applied.Results SOD level went up and LPO level went down 48 hours after HBO group's initial therapy in both of the two groups between which there were no clear differences(P>0.05),but SOD level went up and LPO level went down significantly in HBO group in the second week when compared with that of control group(P<0.01).Not only the good recovery rate was obviously higher but also the death rate was clearly lower in HBO group than in control group(P<0.05).Conclusion The production of oxygen-derived free radicals is effectively inhibited by HBO and so is lipid peroxidatic reaction.Thus,HBO is capable of protecting cerebral tissue's structure and function and improving the severe cerebral damage patients' prognoses.