小剂量氨茶碱联合激素在咳嗽变异性哮喘治疗中的效果研究

目的：观察小剂量氨茶碱联合激素治疗咳嗽变异性哮喘的效果。方法：将60例咳嗽变异性哮喘患者随机分为观察组和对照组,每组各30例,对照组睡前吸入二丙酸倍氯米松300μg/d,14d后减至200μg/d,1个月后为100μg/d。观察组在对照组的基础上,使用小剂量氨茶碱0.2g/d,14d后减至0.1g/d,1个月后为0.05g/d,睡前口服,疗程为6个月,观察两组的治疗效果。结果：观察组哮喘发作次数、每次发作持续时间均低于对照组（P〈0.05）,肺功能指标最大呼气流量（PEF）高于对照组（P〈0.01）。结论：小剂量氨茶碱联合二丙酸倍氯米松具有协同作用,对咳嗽变异性哮喘控制有良好效果,且能改善肺功能。

The effect of low-dose aminophylline and steroid in the treatment of cough variant asthma study

Objective：To observe the low-dose aminophylline and steroid treatment of cough variant asthma.Methods：60 patients with cough variant asthma were randomly divided into two groups and the control group,30 cases in each group and control group before going to bed inhaled beclomethasone dipropionate 300 μg/d,14 days later reduced to 200 μg/d,1 month after 100 μg/d.Observation group were based on the use of small doses of aminophylline 0.2 g/d,14 days later reduced to 0.1 g/d,1 month after the 0.05 g/d,bedtime orally for 6 months observation of curative effects were observed. Results：The frequency of asthma attack group,the duration of each attack were lower than the control group（P0.05） ,peak expiratory flow indices of pulmonary function（PEF） control group（P0.01） .Conclusion：Low dose aminophylline BDP synergistic effect on cough variant asthma control has a positive effect,and can improve lung function.