Gonococcal lipopolysaccharide: A toxin for human fallopian tube mucosa |
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Authors: | C.R. Gregg M.A. Melly Z.A. McGee |
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Affiliation: | 1. George Hunter Laboratory, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA;2. Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. |
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Abstract: | Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection. |
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Keywords: | Reprint requests: Clark R. Gregg M.D. George Hunter Laboratory Division of Infectious Diseases Department of Medicine Vanderbilt University School of Medicine Nashville Tennessee 37232. |
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