调脂康胶囊不同提取部位对高血脂大鼠脂质水平的影响

目的探讨调脂康胶囊对高血脂大鼠脂质水平影响的有效部位。方法采用饮食性高血脂大鼠模型,用极性由小到大的3种有机溶剂和水依次萃取调脂康胶囊,所得各提取部位组分别给大鼠ig给药,测定血清三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和肝脏TG、TC的变化。结果大鼠灌高脂乳剂4周后,模型组大鼠血清TC、TG、LDL-C均较正常组明显升高,肝中TC、TG均明显升高;给药4周后,调脂康胶囊氯仿提取部位组、乙酸乙酯提取部位组、正丁醇提取部位组、水部位组、全方组均能显著降低血清TC、LDL-C水平（P〈0.05或P〈0.01）;正丁醇提取部位组、全方组能显著降低血清TG水平;正丁醇提取部位组能显著降低TC、TG、LDL-C,且与全方比较差异无显著性（P〉0.05）;正丁醇提取部位组、水部位组、全方组与模型组比较,肝中TC明显降低（P〈0.05或P〈0.01）,乙酸乙酯提取部位组、全方组与模型组比较,肝中TG明显降低（P〈0.05）。结论调脂康胶囊乙酸乙酯和正丁醇提取物对高血脂大鼠有降脂作用。

Effects of extractions of Tiaozhikang capsules extracted with on the lipid levels in diet-induced hyperlipidemic rats

Objective To study lipid-lowering effects of extractions of Tiaozhikang capsules extracted with chloroform,acetic ether,n-butyl alcohol,water.Methods Extractions of Tiaozhikang capsules were extracted with four organic solvents in sequence according to their polarities from higher to lower.Then the extractions were intragastrically administered to diet-induced hyperlipidemic rats,and changes in serum triacylglycerol level(TG),serum total cholesterol level(TC),serum high density lipoprotein cholesterol level...