| 产前应激对子代的影响及潜在作用机制 |
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| 引用本文： | 郑阿迪,刘健康,冯智辉.产前应激对子代的影响及潜在作用机制[J].中国病理生理杂志,2014,30(3):558-562. |
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| 作者姓名： | 郑阿迪 刘健康 冯智辉 |
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| 作者单位： | 西安交通大学生命科学与技术学院，生物医学信息工程教育部重点实验室,前沿科学技术研究院，线粒体生物医学研究所，陕西 西安 710049 |
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| 基金项目： | 国家自然科学基金资助项目（No.81201023） |
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| 摘 要： |
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| 关 键 词： | 产前应激 下丘脑-垂体-肾上腺轴 氧化性应激 炎症 营养预防 |
| 收稿时间： | 2013-10-08 |
Effects of prenatal stress on development and health of offspring and its potential mechanisms |
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| ZHENG A-di,LIU Jian-kang,FENG Zhi-hui.Effects of prenatal stress on development and health of offspring and its potential mechanisms[J].Chinese Journal of Pathophysiology,2014,30(3):558-562. |
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| Authors: | ZHENG A-di LIU Jian-kang FENG Zhi-hui |
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| Institution: | Institute of Mitochondrial Biology and Medicine, Frontier Institute of Science and Technology,The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China. |
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| Abstract: | Inappropriate diet and stress in maternal pregnancy may affect the development of the offspring. Brain dysfunction and some chronic diseases such as obesity and diabetes in offspring are associated with the factors during maternal pregnancy. Many researches focused on how prenatal stress affected cognitive function and behavior of the offspring and how nutritional modulation might prevent the pathogenesis of such diseases. Here we summarize the effects of prenatal stress on the offspring and the potential mechanism, like hypothalamus-pituitary-adrenal axis(HPA), oxidative stress, apoptosis and inflammation, and the prevention of nutrient to offspring dysfunction by prenatal stress, based on our previous work and some existing references. |
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| Keywords: | Prenatal stress Hypothalamus-pituitary-adrenal axis Oxidative stress Inflammation Nutrition prevention |
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