同侧肾脏同时发生透明细胞型与乳头状肾细胞癌

目的探讨同侧肾脏发病并且相对独立的透明细胞型和肾乳头状细胞癌的临床病理特点及免疫表型，提高对该肿瘤的认识和诊断水平。方法本研究回顾了2例病理诊断为透明细胞型合并肾乳头状细胞癌的临床资料，通过光镜和免疫组织化学染色，针对肾细胞癌相关蛋白标志物包括 Vimentin、CD10、CK（AE1/AE3）、CK7、CK8/18、PAX2、PAX8、CAⅨ、AMACR]进行了观察和分析。结果2例患者为男性，年龄分别为70、63岁。2例患者的两处独立肿瘤均位于左侧肾脏，镜下观察均可见两处独立肿瘤，肿瘤间隔有正常肾脏组织，分别为乳头状肾细胞癌及透明细胞型肾细胞癌，且免疫组化显示2例患者肿瘤的表型一致。结论单侧肾脏肾透明细胞癌合并肾乳头状细胞癌是一种少见的临床现象，这种现象的存在以及类似的免疫组化表型提示透明细胞型肾细胞癌和乳头状肾细胞癌在发生过程中可能存在着内部的联系。

Renal clear cell carcinoma combine with papillary renal cell carcinoma in unilateral kidney

Objective To study the clinical pathological features of clear cell renal cell carcino-ma coexisted with papillary renal cell carcinoma in unilateral kidney. Methods 2 cases of renal clear cell carcinoma coexisted with papillary renal cell carcinoma were reviewed.The pathologic char-acters and immunohistochemistry results were analyzed.The primary antibodies for immunohisto-chemistry were Vimentin,CD10,CK （AE1/AE3 ）,CK7,CK8/18,PAX2,PAX8,CA Ⅸ and AMACR. Results 2 cases were male.Age 70 years old,63 years old respectively.The two inde-pendent tumors of 2 cases were both located in the left kidney.Microscopically,the two independent tumors were clear cell renal cell carcinoma and papillary renal cell carcinoma respectively.2 cases of patients had similar immune-phenotype by immunohistochemistry results. Conclusions Clear cell renal cell carcinoma coexisted with papillary renal cell carcinoma is rare.It implies there might be some relationship between two types of kidney malignancies during their development.