血清视黄醇结合蛋白 前白蛋白 总胆汁酸 胆碱酯酶检测在肝脏疾病中的临床意义

目的：探讨视黄醇结合蛋白（RBP）、前白蛋白（PA）、总胆汁酸（TBA）、胆碱酯酶（CHE）在不同类型肝脏疾病中的临床价值。方法应用全自动生化分析仪分别检测110例不同类型肝脏疾病患者RBP、PA、TBA、CHE、丙氨酸氨基转移酶（ ALT）、天冬氨酸氨基转移酶（ AST）水平，观察不同肝病组各项指标的变化，并与68名健康体检者（健康对照组）进行对比分析。结果重症肝炎组、肝硬化组及肝癌组中RBP、PA浓度显著低于健康对照组（ P＜0.01）；五组肝病患者TBA水平显著高于健康对照组（ P＜0.01）；重症肝炎组、肝硬化组及肝癌组中的CHE活力显著低于健康对照组（ P＜0.01）；急性病毒性肝炎组、重症肝炎组ALT、AST活力显著高于健康对照组（ P＜0.01）。结论检测血清RBP、PA、TBA、CHE对肝脏疾病的诊断、治疗和判断预后有一定的临床意义，在反映肝脏实质性病变程度方面优于ALT、AST。 ALT、AST检测同时联合RBP、PA、TBA、CHE检测能更好地反映肝脏功能。

The clinical value of detection of RBP, PA, TBA, CHE in different types of liver disease

Objective To study the clinical value of RBP , PA, TBA, CHE in different types of liver disease.Methods The levels of RBP, PA, TBA, CHE, alanine aminotransferase（ALT）, aspartate aminotransferase （ AST） in 110 patient with different types of liver disease were detected respectively by automatic biochemistry analyzer to observe changes in different liver disease groups , and 68 healthy persons （ control group ） were analyzed at the same time.Results The levels of RBP , PA in severe hepatitis group , cirrhosis and liver cancer groups were significantly lower than that in healthy controls （ P〈0.01 ） .The TBA levels in 5 groups of patients with liver disease was significantly higher than that in healthy controls （ P〈0.01 ） .But the cholinesterase activity in severe hepatitis , cirrhosis and liver groups were significantly lower than that in the control group （ P〈0.01 ） .The activity of ALT and AST in acute viral hepatitis , severe hepatitis groups were increased significantly .Conclusion It is suggested that detecting the levels of RBP, PA, TBA, CHE has some clinical significance for the diagnosis , treatment, and prognosis of liver disease , and is better than of detecting ALT , AST in the reflect the liver substantive lesions .Detection com-bined with RBP , PA, TBA, CHE can better reflect liver function .