| 卵巢浆液性腺癌组织中MMP-2、MT1-MMP的表达变化及意义 |
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| 引用本文： | 蒋艳霞,魏志敏,邢晓明,侯峰,付伟伟,李玉军. 卵巢浆液性腺癌组织中MMP-2、MT1-MMP的表达变化及意义[J]. 山东医药, 2010, 50(6): 4-6 |
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| 作者姓名： | 蒋艳霞 魏志敏 邢晓明 侯峰 付伟伟 李玉军 |
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| 作者单位： | 青岛大学医学院附属医院,山东,青岛,266003 |
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| 摘 要： | 目的观察卵巢浆液性腺癌中的基质金属蛋白酶-2（MMP-2）、膜型基质金属蛋白酶-1（MT1-MMP）的表达变化。方法采用免疫组化PV6000法检测50例卵巢浆液性腺癌、30例卵巢交界性浆液性腺瘤和30例卵巢良性浆液性腺瘤组织中的MMP-2、MT1-MMP。结果MMP-2和MT1-MMP在卵巢浆液性腺癌和交界性浆液性腺瘤中的表达阳性率高于良性浆液性腺瘤（P〈0．05）。卵巢良性浆液性腺瘤组织中的MMP-2、MT1-MMP与病理分级、淋巴结转移、临床分期和预后有关（P均〈0．0．5）。卵巢浆液性腺癌中MMP-2、MT1-MMP的表达呈正相关（L=0．61，P〈0．01）。结论卵巢浆液性腺癌中MMP-2、MT1-MMP表达上调。二者在卵巢浆液性腺癌的发生、浸润和转移中过程中协同发挥重要作用，可作为判断肿瘤恶性程度和预后的重要指标。
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| 关 键 词： | 卵巢肿瘤 卵巢浆液性腺癌 基质金属蛋白酶 转移 |
Expression and mechanism of MMP-2 and MT1-MMP in ovarian serous adenocarcinoma tissue |
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| JIANG Yan-xia,WEI Zhi-min,XING Xiao-ming,HOU Feng,FU Wei-wei,LI Yu-jun. Expression and mechanism of MMP-2 and MT1-MMP in ovarian serous adenocarcinoma tissue[J]. Shandong Medical Journal, 2010, 50(6): 4-6 |
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| Authors: | JIANG Yan-xia WEI Zhi-min XING Xiao-ming HOU Feng FU Wei-wei LI Yu-jun |
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| Affiliation: | JIANG Yan-xia,WEI Zhi-min,XING Xiao-ming,HOU Feng,FU Wei-wei,LI Yu-jun.(Affiliated Hospital,Medical College,Qingdao University,Qingdao 266003,P.R.China) |
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| Abstract: | Objective To observe the the expression of MMP-2 and MT1-MMP in ovarian serous adenocarcinoma tissue,and explore its mechanism.Method Immunohistochemical PV6000 method was used to detect the expression of MMP-2 and MT1-MMP in 30 benign serous adenomas,30 borderline serous adenomas and 50 serous adenocarcinomas of ovary.Results The positive expression rates of MMP-2 and MT1-MMP in human ovarian serous adenocarcinomas and borderline serous adenomas were higher than that in human benign serous adenomas(P<0.05)... |
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| Keywords: | ovarian neoplasm ovarian carcinoma matrix metalloproteinase metastasis |
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