130例多发性骨髓瘤的实验室分析

目的研究多发性骨髓瘤(Multiple Myelome，MM)细胞形态学及其他实验室相关指标特征，提高对多发性骨髓瘤的认识。方法回顾性分析130例多发性骨髓瘤患者的实验室检查资料，其中瘤细胞比例按照Greipp标准，重新进行评估。结果130例多发性骨髓瘤中，97例有不同程度的贫血(血红蛋白平均为92g／L)；120例血沉增加，平均为106．5mm／h；蛋白尿56例，平均为( )；本组中有81例肾功能有病理性改变，尿素氮平均为19．3mmol／L；有101例做尿本周氏。阳性为46例，占45．6％；101例血清球蛋白增高，平均为77．69％；骨髓穿刺瘤细胞比例4．5％～76．5％(平均40．5％)。结论多发性骨髓瘤细胞形态学诊断结合实验室相关指标检查，能够提高多发性骨髓瘤诊断的准确性，为临床诊断提供可靠依据。

Laboratory analysis of 130 patients with multiple myeloma

Objectives To explore the cytomorphology and other related laboratory features of multiple myeloma (MM).Methods Laboratory data of 130 previous patients with MM were analysed,among which the proportion of cancer cell were analysed again according to the Greipp Standard.Results Among 130 patients with MM,97 of them have various degrees of hemopthisis (the average level of Hb is 92 g/L);120 of them have growth of eruthrocutes sedimentation rate and the average level is 106.5 mm/h;56 of them have proteinuria and the average is (+) ;81 of them have pathological change in their nephric function and the average level of urea mitrogen is 19.3 mmol/L;101 of them have tested this week urine proteir positive accounting to 15.6%;101 of them have growth in serum globulin and the average level is 77.69%;and the proportion of tumor cells in bone marrow puncture (the average level is 40.5%).Conclusion The cytomorphology together with related laboratory analysis of MM may increase the accuracy tate of MM and provide reliable foundation to clinical diagnosis.