厄贝沙坦和赖诺普利联合应用对高血压病患者血管内皮功能的影响

目的探讨厄贝沙坦、赖诺普利单独与联合治疗对高血压患者血浆一氧化氮(NO)和内皮素(ET)的调节作用。方法选择156例高血压患者,随机分为3组,51例接受厄贝沙坦治疗;55例接受赖诺普利治疗;联合治疗组50例接受厄贝沙坦和赖诺普利治疗。均于治疗前后行血压及血浆NO、ET测定。并与50例健康者血浆NO、ET对照。结果3组高血压患者NO较对照组显著降低(P<0.01),ET显著升高(P<0.01)。3组治疗后血压均有显著下降(P<0.01),厄贝沙坦组及赖诺普利组降压幅度无差异,联合用药组降压幅度明显高于两单独治疗组(P<0.05);3组血浆NO水平均有显著升高(P<0.01);厄贝沙坦组及赖诺普利组血浆NO水平升高幅度无差异(P>0.05),联合用药组NO升高幅度明显高于两单独治疗组(P<0.05);3组血浆ET水平均有显著降低(P<0.01),厄贝沙坦组及赖诺普利组ET水平下降幅度无差异(P>0.05),联合用药组ET下降幅度明显高于两单独应用组(P<0.05)。结论厄贝沙坦、赖诺普利长期单独应用可明显降低血压,同时升高血浆NO水平、降低血浆ET水平、改善血管内皮素功能。两药联用治疗高血压对改善血管内皮功能效果更好。

Effect of combined treatment by irbesartan and lisinopril on vascular endothelial function in patients with essential hypertension

Objective To study the effects of irbesartan and lisinopril used individually or in combination on plasma Nitric Oxide(NO) and endothelin(ET) in essential hypertension patients(EH).Methods One hundred and fifty-six patients with EH were divided randomly into three groups: irbesartan,lisinopril and combined treatment group.50 healthy subjects were selected as control group.The blood pressure,NO and ET were measured before and after treatment.Results The blood pressures in three groups were significantly reduced(P<0.01); the levels of NO were significantly higher than that of control groups(P<0.01); the levels of ET were significantly increased(P<0.01).The combination of two drugs resulted in a more pronounced decrease in blood pressure and ET,and a greater increase in NO than either agent alone(P<0.05).Conclusion Both irbesartan and lisinopril can decrease the blood pressure and ET,increase NO and improve the endothelial function.The combination of two drugs should be a more effective tool.