有机磷杀虫药中毒程度与心肌损伤关系的探讨

目的 探讨有机杀虫药中毒程度与心肌损伤的关系。方法 对247例不同程度中毒患者血清心肌肌钙蛋白Ⅰ（CTn—Ⅰ）和肌酸激酶（CK—MB）同步检测，同时设立40例健康献血员作为对照组，并将实验资料进行统计学分析。结果重度中毒、中度中毒、轻度中毒和对照组CTn—Ⅰ阳性率分别为100．00％（126／126）、65．79％（50／76）、17．78％（8／45）、0．00％（0／40），CK—MB活性升高率分别为100．00％（126／126）50％（38／76）、8．89％（8／45）、0．00％（0／40o组间比较除轻度中毒组CK—MB活性升高率与对照组比较差异无显著统计学意义（P〉0．05），其余各组间差异均有显著统计学意义（P〈0．01）。结论 有机杀虫药中毒程度与心肌损伤有正相关关系。

The relationship between the toxic degrees of organophosphorus insecticides and myocardial injuries

Objective To explore the relationship between the toxic degrees of organophosphorus insecticides and myocardial injuries.Methods The serum cardio troponin-I(CTn-I) and creatine kinase-MB(CK-MB) were assayed simultaneously for 247 cases suffered the toxication of organophosphorus insecticides(group A) and 40 cases of health blood donors(group B).Group A was divided into three subgroups.They are severe,moderate and mild toxication.The laboratory data of the two groups were analysed statistically.Results The positive rates of CTn-I in group A(3 subgroups) and group B were 100.00%(126/126),65.79%(50/76),17.78%(8/45),0.00%(0/40) respectively.The active rates of CK-MB were 100.00%(126/126),50.00%(38/76),8.89%(4/45),0.00%(0/40) respectively.Each of subgroups was campared with group B,but the subgroup of mild toxication,there weren't significant differences(P>0.05).Conclusion There was a positive relativity between the toxic degrees of organophorsphorus insecticides and myocardial injuries.