Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy. |
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| Authors: | Phil Hyu Lee Seung Hyeon Yeo Hyun Joon Kim Hyo Young Youm |
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| Affiliation: | Department of Neurology, Ajou University College of Medicine, Suwon, South Korea. phisland@chol.com |
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| Abstract: | We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD. |
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| Keywords: | olfactory function cardiac MIBG Parkinson's disease |
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