N-乙酰基转移酶2基因多态性与膀胱癌的易感性在亚洲人群中的Meta分析

目的:运用Meta分析的方法综合评价N-乙酰基转移酶2(NAT2)基因多态性与膀胱癌发病的关系。方法:通过文献检索策略对常见的英文和中文数据库进行检索,将检索到的已经发表关于亚洲人群中NAT2基因多态性与膀胱癌关联性的文献进行整合及Meta分析。结果:NAT2慢基因易感性合并OR值及其95%CI为1.67(1.32,2.12)。按亚洲人群进行分层,中国、日本、韩国及印度人群NAT2慢基因易感性合并OR值分别为1.67(1.36~2.05)、2.19(1.71~2.82)、0.78(0.45~1.38)和1.41(0.94~2.12);按是否吸烟进行分层发现吸烟组NAT2慢基因与膀胱癌有关(OR=2.57,95%CI:1.84~3.59),而不吸烟组中未见NAT2慢基因与膀胱癌存在关联(OR=1.36,95%CI:0.92~2.02)。按是否暴露在联苯胺、芳香胺等胺类物质中进行分层发现暴露组中NAT2慢基因与膀胱癌易感性尚不能发现关联(OR=1.99,95%CI:0.49~8.00),而非暴露组中发现NAT2慢基因与膀胱癌易感性存在关联(OR=2.17,95%CI:1.26~3.72)。结论:亚洲人群NAT2基因多态性与膀胱癌易感性存在关联,NAT2基因多态性与膀胱癌易感性的关系在不同地区、不同种族间可能会有所不同。吸烟可能会增加个体患膀胱癌的危险性;而本次研究未发现携带有NAT2慢基因个体暴露在联苯胺、芳香胺等胺类物质中会增加膀胱癌的易感性,可能与研究暴露因素的样本量过少有关。

NAT2 genetic polymorlhism and bladder cancer susceptibility：A meta-analysis in Asia population

Objective： To investigate the association between N-acetyltransferase 2 （NAT2） polymorphism and susceptibility to bladder cancer by the method of rueta-analysis, Method： By literature search strategies in both English and Chinese database, the eligible published records about NAT2 genetic polymorphism and bladder cancer in Asian population were identified in this meta-analysis. Result： The pooled ORs （95 ~CI） for studies with sus- ceptibility of slow NAT2 were 1.67 （1.32, 2.12）. Stratified by different regions in Asian area, and the ORs for susceptibility of slow NAT2 among Chinese, Japanese, Korean and Indian population were 1.67 （1.36-2.05） and 2.19 （1.71-2.82） and 0. 78 （0.45-1.38） and 1.41 （0, 94-2.12）, respectively. Stratification analysis showed that OR for the slow NAT2 gene and bladder cancer among the smoking group was 2.57 （95 %0 CI： 1.84-3.59）. OR for the slow NAT2 gene and bladder cancer among the non-smoking group was 1.36 （95% CI： 0.92-2.02）. Stratification analysis showed that OR for the slow NAT2 gene and bladder cancer susceptibility among the exposed group （such as Benzidine, aromatic amine） was 1.99 （95 % CI： 0. 49-8. 00）. OR for the slow NAT2 gene and bladder cancer susceptibility among the no-exposed group was 2.17 （950% CI： 1.26-3.72）. Con-clusion： NAT2 genetic polymorphism is associated with susceptibility of bladder cancer in Asian population. The relationship between NAT2 genetic polymorphism and bladder cancer susceptibility in different regions may be va- rious because of different races. Tabaco smoking may increase the risk of bladder cancer individually. However, for the possible reason of small sample size no association was found that in the group from NAT2 slow acetylated genetic individuals exposed to Benzidine, aromatic amine could increase the risk of bladder cancer susceptibility.