| 糖尿病肾病足细胞损伤的病理机制及中药的干预作用 |
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| 引用本文： | 石格,毛志敏,万毅刚,沈山梅,吴薇,杨晶晶,姚建.糖尿病肾病足细胞损伤的病理机制及中药的干预作用[J].中国中药杂志,2016,41(13):2416-2421. |
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| 作者姓名： | 石格 毛志敏 万毅刚 沈山梅 吴薇 杨晶晶 姚建 |
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| 作者单位： | 南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210029,南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210029,南京大学医学院 附属鼓楼医院 中医科, 江苏 南京 210008,南京大学医学院 附属鼓楼医院 内分泌科, 江苏 南京 210008,南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210029,南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210029,Division of Molecular Signaling, Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan |
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| 基金项目： | 国家自然科学基金面上项目（81374030，81573903） |
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| 摘 要： | 在糖尿病肾病(diabetic nephropathy,DN)进程中,足细胞损伤与蛋白尿密切相关。足细胞损伤的病理特征主要是指足细胞形态和功能的改变,包括足突融合、足细胞数量和密度减少、足细胞凋亡、足细胞上皮-间充质转分化以及足细胞肥大等。这些病理性损伤受控于肾组织内多条信号调控途径,如哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,m TOR)/自噬通路、转化生长因子(transforming growth factor,TGF)-β1通路以及Notch通路等。以雷公藤制剂为代表的一些中药提取物,如雷公藤多苷(multiglycoside of Tripterygium wilfordii,GTW)、雷公藤甲素(triptolide,TP)、黄芪多糖(astragalus polysaccharide,APS)、黄芪甲苷(astragaloside IV,AS-IV)以及三七总皂苷(Panax notoginseng saponins,PNS)在体内外对DN模型鼠足细胞病变或高糖诱导的足细胞损伤都具有一定的保护作用。国内的初步研究表明,GTW很可能通过调控DN模型鼠肾组织m TORC1信号通路活性而改善足细胞损伤。因此,基于DN足细胞损伤的信号调控途径而探讨中药干预作用的研究是今后的发展方向。
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| 关 键 词： | 糖尿病肾病 中药 足细胞 病理机制 mTOR/自噬信号通路 |
| 收稿时间： | 2016/4/12 0:00:00 |
Pathomechanisms of podocyte injury in diabetic nephropathy and interventional effects of Chinese herbal medicine |
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| SHI Ge,MAO Zhi-min,WAN Yi-gang,SHEN Shan-mei,WU Wei,YANG Jing-jing and YAO Jian.Pathomechanisms of podocyte injury in diabetic nephropathy and interventional effects of Chinese herbal medicine[J].China Journal of Chinese Materia Medica,2016,41(13):2416-2421. |
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| Authors: | SHI Ge MAO Zhi-min WAN Yi-gang SHEN Shan-mei WU Wei YANG Jing-jing and YAO Jian |
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| Institution: | Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China,Department of Endocrinology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China and Division of Molecular Signaling, Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan |
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| Abstract: | |
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| Keywords: | diabetic nephropathy Chinese herbal medicine podocyte pathomechanism mTOR/autophagy signaling pathway |
| 本文献已被 CNKI 等数据库收录！ |
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