麻仁软胶囊治疗抗精神病药物所致便秘的临床观察

目的探讨麻仁软胶囊治疗抗精神病药物致便秘的临床疗效。方法将服用抗精神病药物致便秘的192例住院精神病患者随机分成3组,各64例,分别给予麻仁软胶囊、番泻叶、酚酞(果导)片治疗,用药后观察排气,记录排便时间以及腹痛、腹胀情况。结果 3种药物通便疗效总有效率均在80%以上,3组间无显著性差异(P0.05);麻仁软胶囊组患者治疗依从性显著高于番泻叶和酚酞片组(P0.01);且番泻叶、酚酞片有不同程度的腹痛、腹泻等副作用,麻仁软胶囊组不良反应发生率显著低于番泻叶组、酚酞片组(P0.01)。结论麻仁软胶囊治疗抗精神病药物所致便秘疗效显著,患者依从性高,不良反应少。

Clinical observation on Maren Soft Capsule in treatment of antipsychotic drug-induced constipation

Objective To investigate the clinical effect of Maren Soft Capsule (MSC) in the treatment of constipation induced by antipsychotic drugs. Methods Totally 192 hospitalized psychiatric patients with constipation caused by antipsychotic drugs were randomly divided into three groups, there wer 64 cases in each group. The first group was treated with MSC, the second group was given Sennae Folium, and the third group was given Phenolphthalein Tablets. The exhaust, defecation time, abdominal pain, and abdominal distension were observed after the treatment. Results The total effect rates of the three drugs were over 80%. There was no significant difference in the effect of three drugs (P > 0.05), but Sennae Folium and Phenolphthalein Tablets had different degrees of side effects such as diarrhea and abdominal pain. Occurrence of adverse reaction rate of MSC was significantly lower than that of Sennae Folium and Phenolphthalein Tablets (P < 0.01). Conclusion The effect of MSC in the treatment of antipsychotic drugs-induced constipation is significant, and the incidence of adverse reactions is low.