| 血管外膜炎症对内膜增殖及P-选择素表达水平的影响 |
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| 引用本文： | 唐蓉,李卫华,谢强,黄峥嵘.血管外膜炎症对内膜增殖及P-选择素表达水平的影响[J].临床心血管病杂志,2011,27(3):197-199. |
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| 作者姓名： | 唐蓉 李卫华 谢强 黄峥嵘 |
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| 作者单位： | 厦门大学附属第一医院心内科,福建厦门,361003 |
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| 基金项目： | 福建省卫生厅青年基金(No:2005-39); 厦门市重大疾病研究项目(No:XMWZK0603) |
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| 摘 要： | 目的:研究脂多糖诱导兔股动脉外膜炎症对内膜增生的影响,探讨外膜炎症对内膜增生影响的分子机制.方法:成年新西兰大耳白兔30只,术前均喂以高脂饮食2周.两侧的股动脉随机分为脂多糖组和对照组.于术后1 h、3 d和2周分别处死10只动物获得股动脉标本,观察形态学变化和血管内膜增生情况,并用免疫组化方法观察P-选择素在动脉壁的...
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| 关 键 词： | 主动脉疾病 炎症 外膜 脂多糖 P-选择素 |
Effect of adventitia inflammation on neointimal proliferation and P-selectin expression |
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| TANG Rong,LI Weihua,XIE Qiang,HUANG Zhenrong.Effect of adventitia inflammation on neointimal proliferation and P-selectin expression[J].Journal of Clinical Cardiology,2011,27(3):197-199. |
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| Authors: | TANG Rong LI Weihua XIE Qiang HUANG Zhenrong |
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| Institution: | TANG Rong LI Weihua XIE Qiang HUANG Zhenrong(Department of Cardiology,the First Hospital Affiliated to Xiamen University,Xiamen,361003,China) |
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| Abstract: | Objective:To investigate the influence of adventitial inflammation on intimal prolifration of arteries and to clarify the molecular mechanism of P-selectin as a marker of inflammation.Method:Thirty New ZeaLand white rabbits were fed with high cholesterol diet for 2 weeks,two sides of iliac arteries were randomly divided into two groups: LPS group(n=30) and control group(n=30).A nonconstrictive polyethylene cuff was placed loosely around the femeral artery of the rabbit.Between the artery and the cuff,a ster... |
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| Keywords: | aortic diseases inflammation adventitia LPS P-selectin |
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