社区人群高尿酸血症危险因素的病例对照研究

目的 探讨社区人群(20岁以上)高尿酸血症的危险因素。方法 采用病例对照研究方法,对研究对象进行单因素与多因素logistic回归分析。结果 经单因素筛选,有17个暴露因素与高尿酸有关;多因素分析,有5个因素在P=0.05水平被选入,高甘油三酯(OR=3.069)、饮酒(OR=2.032)、肥胖(OR=1.802)、口味偏辣(OR=1.877)、高血糖(OR=1.622)在模型中是高尿酸血症的独立危险因素。结论 高尿酸血症是一种与环境和生活方式有关的疾病,改变生活方式,如减少饮酒和合理饮食结构可能预防或减少高尿酸血症的发生,进而减少痛风的发生。

A community-based case-control study on risk factors of hyperuricemia among residents in the community

OBJECTIVE: To investigate the risk factors of hyperuricemia among residents aged >/= 20 years. METHODS: A community based case-control study was conducted in 286 patients with 858 controls without hyperuricemia. Available data were analyzed by mono-factorial and multi-factorial logistic regression methods using SPSS 10.0 software. RESULTS: 17 factors related to exposure were identified for hyperuricemia the mono-factorial analysis when; five factors were selected through multiple factoral logistic regression model at P = 0.05 level. The risk factors on hyperuricemia were: hypertriglyceridemia (OR = 3.069), alcohol consumption (OR = 2.032), obesity (OR = 1.802), taste of spicy food (OR = 1.877) and hyperglycemia (OR = 1.622). CONCLUSION: Hyperuricemia is a disease associated with environment and style-life. Changing lifestyle, such as decreasing alcohol consumption and adopting proper structure of diet may prevent or decrease the chance of getting hyperuricemia and gout.