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降钙素原联合C-反应蛋白检测对新生儿败血症的临床诊断价值
引用本文:冯家伍,吴显劲,钟琼,廖德权.降钙素原联合C-反应蛋白检测对新生儿败血症的临床诊断价值[J].河北医学,2010,16(7):791-793.
作者姓名:冯家伍  吴显劲  钟琼  廖德权
作者单位:广东医学院附属医院检验科,广东,湛江,524001
摘    要:目的:探讨血清降钙素原(PCT)联合C反应蛋白(CRP)检测对新生儿败血症诊断的临床价值。方法:化学发光免疫法测定血浆PCT含量和散射比浊法测定血浆CRP水平。结果:败血症患儿中PCT(78.85±19.16ng/mL)和CRP(53.17±35.68mg/L)水平明显高于正常对照组(0.35±0.13ng/mL和5.87±3.77mg/L),差异有统计学意义(P〈0.01);PCT的特异性、阳性预测值、准确性性和约登指数高于CRP。PCT和CRP水平与患儿病情的严重程度呈正相关。结论:血清PCT联合CRP测定可为新生儿败血症诊断提供更准确的诊断依据。

关 键 词:降钙素原  C反应蛋白  败血症

Serum Procalcitonin and C Reactive Protein in Diagnosis of Neonatal Sepsis Patients
Institution:FENG Jiawu,WU Xianjin,ZHONG Qiong,et al(The Affiliated Hospital of Guangdong Medical College,Guangdong Zhanjiang 524001,China)
Abstract:Objective:To evaluate the clinical significance of the detection of serum procalcitonin(PCT)and C reactive protein(CRP) in the diagnosis of neonatal sepsis.Method: PCT was determined by chemiluminescence immunoassay and CRP was measured by nephelometry.Result: The serum level of PCT and CRP in the neonatal sepsis group was(78.85±19.16)ng/mL and(53.17±35.68)mg/L respectively,which were much higher than those in the control group(0.35±0.13)ng/mL and(5.87±3.77)mg/L respectively(P 0.01).PCT and CRP had higher specificity,positive predictive value,accuracy and youden index.The levels of PCT and CRP were positively correlated to the severity of the illness.Conclusion: Concurrent determination of serum PCT and CRP could provide more accurate diagnostic evidence neonatal sepsis patients.
Keywords:Procalcitonin(PCT)  C-reactive protein  Neonatal sepsis
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