The effect of different contraceptive treatments on the serum concentration of dehydroepiandrosterone sulfate |
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Authors: | Karin L. Klove Subir Roy Rogerio A. Lobo |
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Affiliation: | Department of Obstetrics and Gynecology University of Southern California School of Medicine and Women''s Hospital, Los Angeles County/USC Medical Center Los Angeles, California, U.S.A. |
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Abstract: | Twenty-six healthy, non-hirsute women had antecubital venous blood obtained before and during treatment with various contraceptive steroids for the measurement of dehydroepiandrosterone sulfate (DHEA-S). Six of the women were randomized to receive Ortho Novum 1/35 (O/N), 7 were assigned to Ovcon 35 (OV), and another five received Nordette (N). The 6 women ingesting O/N as well as the 7 receiving OV had significant decreases in serum concentrations of DHEA-S (p < 0.05). The percentage of decrease in DHEA-S in the O/N group (39 ± 6%) and in the OV group (30 ± 5%) was not statistically different. The group receiving N showed no changes from baseline measurements. Serum samples from another 8 women who had received subcutaneous implants of levonorgestrel (1-Ng) were obtained. No significant changes occurred in serum DHEA-S between baseline and six-month samples.The data that 1-Ng alone and the combination of 1-Ng and ethinylestradiol did not change DHEA-S levels suggest that 1-Ng does not affect adrenal androgen secretion. Because N, O/N and OV contain similar quantities of ethinylestradiol, these results indicate that norethindrone, but not 1-Ng, has a major suppressive effect upon adrenal androgen secretion. |
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Keywords: | Reprint Requests to: Rogerio A. Lobo MD Women's Hospital Room L913 1240 North Mission Road Los Angeles CA 90033. |
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