| Kisspeptin/GPR54系统与能量代谢的关系 |
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| 引用本文： | 胡雅婷,温俊平,陈刚. Kisspeptin/GPR54系统与能量代谢的关系[J]. 国际内分泌代谢杂志, 2010, 30(2). DOI: 10.3760/cma.j.issn.1673-4157.2010.02.012 |
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| 作者姓名： | 胡雅婷 温俊平 陈刚 |
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| 作者单位： | 福建医科大学省立临床医院内分泌科,福州,350004 |
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| 基金项目： | 国家自然科学基金，福建省科技厅青年人才项目资助项目 |
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| 摘 要： | 营养状态和有效的能量储存可影响生育能力,但是连接能量代谢和生殖的细胞和分子机制还不十分清楚.研究表明,kisspeptin/G蛋白耦联受体(GPR)54系统是生殖系统的主要调控者,但近年的研究发现,能量平衡状态以及一些代谢因子能影响下丘脑KISS-1或GPR54的表达,从而影响下丘脑-垂体-性腺轴的功能.因此,下丘脑kisspeptin/GPR54系统可能在将机体能量代谢信息传递给调控生殖轴的中枢过程中有重要作用.
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| 关 键 词： | 能量代谢 KISS-1基因 生殖 |
Relationship between kisspeptin/GPR54 system and energy metabolism |
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| HU Ya-ting,WEN Jun-ping,CHEN Gang. Relationship between kisspeptin/GPR54 system and energy metabolism[J]. International JOurnal of Endocrinology and Metabolism, 2010, 30(2). DOI: 10.3760/cma.j.issn.1673-4157.2010.02.012 |
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| Authors: | HU Ya-ting WEN Jun-ping CHEN Gang |
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| Abstract: | Fertility is gated by nutrition and the availability of stored energy reserves ,but the cellular and molecular mechanisms link energy stores and reproduction are not well understood.Several lines of evi-dence have substantiated the pivotal function of the kisspeptin/GPR54 system as a major gatekeeper of the re-productive axis.In addition, nutritional status and peripheral signal (s) can modulate the hypothalamic KISS-1/GPR54 system.Accordingly, the hypothalamic kisspeptin/GPR54 system might play a physiological role in relaying the state of body energy stores and metabolic fuels to the centers governing the reproductive axis. |
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| Keywords: | GPR54 |
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