| PGE1脂微球对肺心病并心力衰竭病人脑钠肽影响 |
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| 引用本文： | 章政,王成军,刘志明,王新华,毛拥军.PGE1脂微球对肺心病并心力衰竭病人脑钠肽影响[J].青岛大学医学院学报,2010,46(1):58-59,62. |
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| 作者姓名： | 章政 王成军 刘志明 王新华 毛拥军 |
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| 作者单位： | 青岛大学医学院附属医院特需保健科,山东,青岛,266003 |
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| 基金项目： | 山东省卫生厅课题(鲁健办发[2005]9号) |
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| 摘 要： | 目的观察前列腺素E1脂微球(Lipo PGE1)对肺心病并心力衰竭病人脑钠肽(BNP)的影响。方法将120例肺源心脏病病人随机分为治疗组和对照组,各60例。两组治疗期间均停用其他扩血管药物,给予控制诱因、持续低流量吸氧、强心、利尿等常规抗心力衰竭治疗,积极抗感染、纠正电解质及酸碱失衡等,治疗组在一般治疗基础上给予Lipo PGE110μg/d静脉推注,疗程14 d。比较两组治疗前后血BNP以及心脏指数(CI)。结果两组病人治疗后BNP较治疗前均显著降低(t=2.02、7.91,P<0.05、0.01),治疗组BNP较对照组显著降低(t=4.91,P<0.05)。治疗后两组病人CI较治疗前均显著增加(t=2.00、4.65,P<0.05、0.01),且治疗组CI显著大于对照组(t=3.59,P<0.05)。结论静脉推注Lipo PGE1治疗肺心病并心力衰竭疗效显著,在明显降低BNP的同时可提高CI。
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| 关 键 词： | 前列地尔 肺心病 利钠肽 脑 心脏指数 |
Effect of Lipo PGE1 on plasma level of brain natriuretic peptide in patients with pneumocardial disease complicated cardiac failure |
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| ZHANG ZHENG,WANG CHENG-JUN,LIU ZHI-MING,et al.Effect of Lipo PGE1 on plasma level of brain natriuretic peptide in patients with pneumocardial disease complicated cardiac failure[J].Acta Academiae Medicinae Qingdao Universitatis,2010,46(1):58-59,62. |
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| Authors: | ZHANG ZHENG WANG CHENG-JUN LIU ZHI-MING |
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| Institution: | Department of Geriatrics;The Affiliated Hospital of Qingdao University Medical College;Qingdao 266003;China |
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| Abstract: | Objective To observe the effect of Lipo PGE1 on plasma levels of brain natriuretic peptide(BNP) in patients with pneumocardial disease(PD) complicated heart failure. Methods This study comprised 120 patients with PD,who wereequally randomized to treatment group and control group.During the treatment,other vasodilating agents were discontinued in both groups.They were given control of inducement,inhalation of low-flow oxygen,administration of diuretics and antibiotics.Those in the treatment group,intravenous... |
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| Keywords: | alprostadil pulmonary heart disease natriuretic peptide brain cardiac index |
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