| 舌鳞癌组织中p53,p21基因蛋白的表达及生物学意义 |
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| 引用本文： | 潘朝斌,黄洪章,陈伟良. 舌鳞癌组织中p53,p21基因蛋白的表达及生物学意义[J]. 广东医学, 1999, 20(10): 753-754 |
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| 作者姓名： | 潘朝斌 黄洪章 陈伟良 |
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| 作者单位： | 中山医科大学孙逸仙纪念医院!510120 |
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| 摘 要： | 目的 研究ｐ５３，ｐ５１在舌鳞癌组织的表达及其与肿瘤分级的关系。方法 应用免疫组化ＳＰ法对５４例舌鳞癌组织标本行ｐ５３，ｐ２１癌基因蛋白表达的检测。结果 舌癌组织ｐ５３，ｐ２１癌基因蛋白的阳性率分别为４６．３％，６１．１％；两种癌基因的阳性表达皆与组织分化程度有关；ｐ５３基因的阳性表达与ｐ２１原阳性表达有关。
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| 关 键 词： | 舌肿瘤 癌基因蛋白 免疫组织学 p53 p21 |
The expressions of p53 and p21 proteins in tongue carcinoma and their significance |
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| Pan Chaobin,Huang Hongzhang,Chen Wiliang,et al.. The expressions of p53 and p21 proteins in tongue carcinoma and their significance[J]. Guangdong Medical Journal, 1999, 20(10): 753-754 |
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| Authors: | Pan Chaobin Huang Hongzhang Chen Wiliang et al. |
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| Affiliation: | Pan Chaobin,Huang Hongzhang,Chen Wiliang,et al. Sun Yat-sen Memorial Hospital,Sun Yat-sen University of Medical Sciences,510120 |
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| Abstract: | Objective To study the expressions of p53 and p21 proteins in tongue carcinoma and their significance. Methods The expressions of p53 and p21 proteins in 54 cases with tongue carcinoma were determined by immunohistochemical SP method. Results The positive expressions of p53, p21 proteins in tongue carcinoma were 46.3%, 61.1%, respectively. The expressions of p53, p21 proteins were associated with histological grade of differentiation ( P<0.01 ). The p21 protein expression was associated with p53 protein expression ( P<0.05) . Conclusion High positive expressions of p53 and p21 proteins are found in tongue carcinoma. Expressions of p53 and p21 proteins are valuable in determining the degree of malignancy. The occurrence of tongue carcinoma is the result of multi-oncogene mutation. |
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| Keywords: | Protein p53/biosythesis Protein p21/biosythesis Protooncogene protein Immunohistochemistry Tongue neoplasms |
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