尼莫地平用于治疗血管性痴呆的疗效观察

目的评估尼莫地平治疗轻、中度血管性痴呆的疗效。方法对35例轻、中度血管性痴呆（VD）患者给予尼莫地平进行治疗,疗程12周。应用简易精神状态量表（MMSE）及日常生活能力量表（ADL）判定疗效,治疗前后采用经颅多谱勒（TCD）检测平均脑血流速度（VM）及搏动指数（PI）,治疗前后行听觉事件相关电位（P300）检测,同时记录不良反应。结果予尼莫地平治疗后,患者简易精神状态量表（MMSE）及日常生活能力量表（ADL）评分较治疗前有明显改善（P〈0.01）。用药后脑血流速度及搏动指数改善（P〈0.05）,用药后P300潜伏期显著缩短,波幅显著提高（P〈0.01）,尼莫地平不良反应轻。结论尼莫地平治疗轻、中度血管性痴呆有效、安全。

Effect of nimodipine on vascular dementia

OBJECTIVE To evaluate the therapeutic effect of nimodipine on mild/medium Vascular dementia.METHODS Thirty-five patients with Vascular dementia were treated with nimodipine for 12 weeks.Then their MMSE and ADL were evaluated and the Vm and PI were measured by TCD before and after treatment, and P300 was detected before and after treatment. The side effects of the drugs were recorded at the same time. RESULTS The scales of MMSE and ADL were improved after nimodipine treatment （P 〈 0.01）, the Vm and PI were improve after nimodipine treatment （P 〈 0.05）, P300 latencies reduced and amplitudes increased significantly after nimodipine treatment（P 〈 0.01）, The side effects of nimodipine were mild. CONCLUSION modipine has a safe and therapeutic effect on mild/medium Vascular dementia.