| AC－cAMP－PKA途径对淋巴细胞DNA合成的调节作用 |
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| 引用本文： | 李鸣,张茜,杨敬,王晓林,崔武任,叶仙桃.AC－cAMP－PKA途径对淋巴细胞DNA合成的调节作用[J].中国免疫学杂志,1996(3). |
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| 作者姓名： | 李鸣 张茜 杨敬 王晓林 崔武任 叶仙桃 |
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| 作者单位： | 同济医科大学基础医学院免疫学教研室，郑州市空军医院检验科，同济医科大学实验医学研究中心核医学研究室 |
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| 摘 要： | 以ＣＤ３ＭｃＡｂ为激动剂，以淋巴细胞体外ＤＮＡ合成为研究手段，探讨了ＡＣ－ｃＡＭＰ－ＰＫＡ信号途径在ＣＤ３ＭｃＡｂ诱导的淋巴细胞活化中的意义。研究结果表明ＡＣ、ｃＡＭＰ和ＰＫＡ在决定细胞对外界刺激的反应中起着重要作用。在淋巴细胞活化早期细胞内ｃＡＭＰ出现一过性升高，随着细胞活化增殖，ｃＡＭＰ降至正常水平以下。活化ＡＣ、升高细胞内ｃＡＭＰ水平可显著降低ＣＤ３ＭｃＡｂ诱导的淋巴细胞ＤＮＡ合成，而ＰＫＩ却能在一定程度上促进淋巴细胞活化增殖。
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| 关 键 词： | cAMP，腺苷酸环化酶，蛋白激酶A（PKA），淋巴细胞DNA合成 |
THE REGULATION OF AC-cAMP-PKA PATHWAY ON LYMPHOCYTE DNA SYNTHESIS |
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| Li Ming,Zhang Qian,Yang Jing,et al..THE REGULATION OF AC-cAMP-PKA PATHWAY ON LYMPHOCYTE DNA SYNTHESIS[J].Chinese Journal of Immunology,1996(3). |
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| Authors: | Li Ming Zhang Qian Yang Jing |
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| Abstract: | The significance of AC-cAMP-PKA signal system in T cell activation was investigated by lymphocyte DNA synthesis stimulated with CD3 McAb.The results indicated that AC,cAMP and PKA take an important role in determining the response of lymphocytes to the stimulation. During the early period of lymphocyte activation,intracellular cAMP increased and reach its peak at 30min,and then decreased to a level beneath the normal.Activating AC and increasing intercellular cAMP could obviously decrease lymphocyte proliferation induced by,CD3 McAb,and lymphocyte DNA synthesis was increased to some extend by the pretreatment of PKI. |
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| Keywords: | cAMP AC PKA Lymphocyte DNA synthesis |
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