E-选择素介导的炎症反应与冠状动脉内支架术后再狭窄

再狭窄是限制冠状动脉内支架术远期成功的重要因素。它是一个由内皮损伤触发的多种因子参与的损伤修复过程，主要包括：机械损伤内皮处非阻塞性血栓形成、新生内膜增生及血管重构等反应。E-选择素仅表达于活化的内皮细胞表面，主要作用是在炎症发生时介导白细胞与血管内皮细胞的起始黏附，以及介导白细胞之间、白细胞与血小板之间的黏附形成血栓，从而对支架置入后损伤的内膜增生过程产生影响。E-选择素的研究对揭示再狭窄发生机制及寻找新的治疗途径均具有重要意义。

E-selectin Mediated Inflammation and Restenosis after Coronary Stenting

In - stent restenosis is an important factor that limits the long - term success of intracoronary stent implantation. It is a repairing process triggerd by endothelium injury and involving many factors, mainly including the formation of nonocclusive thrombosis in the mechanical - damaged endothelium, neointimal hyperplasia and vascular remodeling. E - selectin only expresses on the activated endothelial cells＇ surface and mediates the initial adhesion of leukocytes to vascular endothelial cells in inflammation and the formation of thrombosis between leukocytes and leukocytes, and between leukocytes and platelets, thus affecting neointimal hyperplasa after coronary stenting. The resesrch of E - selectin is important in revealing the mechanism of restenosis and discovering new therapeutic methods.