依托咪酯对异氟烷镇痛催眠作用的影响

目的：观察依托咪酯对异氟烷镇痛、催眠作用的影响。方法：120只小鼠随机分为3种实验方法组（n=40）,每组再分为4小组（n=10）：生理盐水组,异氟烷组,依托咪酯组,异氟烷和依托咪酯合用组。通过甩尾实验、扭体实验和催眠实验分别观察各组小鼠给药后甩尾潜伏期、扭体次数、睡眠潜伏期、睡眠维持时间和入睡率的变化。结果：依托咪酯能延长异氟烷镇痛小鼠的镇痛时间（P〈0.05）,减少扭体次数（P〈0.05）;缩短小鼠的睡眠潜伏期（P〈0.05）,显著延长小鼠的睡眠维持时间（P〈0.01）并增加小鼠的入睡率。结论：依托咪酯可以增强异氟烷的镇痛、催眠作用。

Influences of Etomidate on the Analgesic and Hypnotic Effects of Isoflurane in Mice

Objective： To observe the influences of etomidate on the analgesic and hypnotic effects of isoflurane. Methods ：120 mice were randomly divided into 3 groups for three tests （n =40） ; and each large group were further divided into 4 small groups （ n = 10） ： normal saline group （ NS group） , etomidate group （ E group） , isoflurane group （Iso group） and the combination of isoflurane and etomidate group （Iso ＋ E group）. Tail - flick latency （TFL） in tail - flick test, writhing times （WTs） in writhing test and sleeping latency （SL）, sleeping time （ST）, sleeping ratio in hypnotic test were employed to observe the variation of each group. Results： Etomidate prolonged the analgesic period of isoflurane in mice （ P 〈 0.05 ） and decreased the WTs （ P 〈 0. 05 ） ; shortened the SL （ P 〈 0. 05 ）, prolonged the ST significantly （P 〈 0. 01 ） and increased the sleeping ratio. Conclusions： Etomidate can reinforce the analgesic and hypnotic effects of isofiurane in mice.